Literature DB >> 2408447

Control of human and animal platelet aggregation by a new prostacyclin analog.

P Maderna, S Colli, C Sirtori, E Tremoli, R Paoletti.   

Abstract

The in vitro effects of ZK 36 374, a new chemically stable prostacyclin (PGI2) analog, on platelet aggregation were studied and compared to those of PGI2. Significantly lower concentrations of ZK 36 374, versus prostacyclin, were required to inhibit collagen and epinephrine-induced aggregation in human platelet-rich plasma. In contrast, in rat and rabbit platelet rich plasma, PGI2 was more effective than ZK 36 374 in inhibiting the aggregation elicited by ADP and collagen. It is concluded that ZK 36 374 is a potent antiaggregatory compound and may be useful in the prevention of cardiovascular disorders.

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Year:  1985        PMID： 2408447

Source DB:  PubMed          Journal:  Adv Prostaglandin Thromboxane Leukot Res        ISSN： 0732-8141


  3 in total

1.  Antimetastatic action of the prostacyclin analog iloprost in the mouse.

Authors:  G Sava; L Perissin; S Zorzet; P Piccini; T Giraldi
Journal:  Clin Exp Metastasis       Date:  1989 Nov-Dec       Impact factor: 5.150

Review 2.  Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures.

Authors:  S M Grant; K L Goa
Journal:  Drugs       Date:  1992-06       Impact factor: 9.546

3.  Effects of adenosine derivatives on human and rabbit platelet aggregation. Correlation of adenosine receptor affinities and antiaggregatory activity.

Authors:  S Dionisotti; C Zocchi; K Varani; P A Borea; E Ongini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-12       Impact factor: 3.000
  3 in total

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