| Literature DB >> 24084159 |
Arndt W Schmidt1, Taylor A Choi, Gabriele Theumer, Scott G Franzblau, Hans-Joachim Knölker.
Abstract
A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.Entities:
Keywords: Anti-TB activity; Cholestanols; Inhibition; Steroids; Tuberculosis
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Year: 2013 PMID： 24084159 DOI： 10.1016/j.bmcl.2013.09.013
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823