BACKGROUND: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP). METHODS: Over a 2-year period, all subjects who were >14 years of age living in the Maresme region (Barcelona, Spain) diagnosed of CAP were registered. Controls were healthy subjects selected from the municipal census. Prognostic factors were assessed and serum levels of total IgG, IgA, IgM, and IgG subclasses were measured at diagnosis and 1 month later (cases). RESULTS: We studied 171 patients with CAP and 90 controls. All immunoglobulins were significantly lower in cases than in controls. At diagnosis, 42.7% of cases showed low levels of some immunologic parameter, mainly total IgG and IgG2. Low immunoglobulin levels at diagnosis were more frequent in patients requiring in-patient care and in those with pneumonia of other etiology than Streptococcus pneumoniae. In the convalescent phase, 26 (23.6%) patients normalized immunological levels. In 27 (24.5%) cases, some parameter with low levels persisted especially in patients with etiology of CAP other than S. pneumoniae. CONCLUSIONS: Low serum levels of immunoglobulins particularly total IgG and IgG2 were a common finding in patients with CAP compared to healthy controls. Low immunoglobulin levels may be related to CAP prognosis and persisted in the convalescent phase in one-fourth of cases.
BACKGROUND: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP). METHODS: Over a 2-year period, all subjects who were >14 years of age living in the Maresme region (Barcelona, Spain) diagnosed of CAP were registered. Controls were healthy subjects selected from the municipal census. Prognostic factors were assessed and serum levels of total IgG, IgA, IgM, and IgG subclasses were measured at diagnosis and 1 month later (cases). RESULTS: We studied 171 patients with CAP and 90 controls. All immunoglobulins were significantly lower in cases than in controls. At diagnosis, 42.7% of cases showed low levels of some immunologic parameter, mainly total IgG and IgG2. Low immunoglobulin levels at diagnosis were more frequent in patients requiring in-patient care and in those with pneumonia of other etiology than Streptococcus pneumoniae. In the convalescent phase, 26 (23.6%) patients normalized immunological levels. In 27 (24.5%) cases, some parameter with low levels persisted especially in patients with etiology of CAP other than S. pneumoniae. CONCLUSIONS: Low serum levels of immunoglobulins particularly total IgG and IgG2 were a common finding in patients with CAP compared to healthy controls. Low immunoglobulin levels may be related to CAP prognosis and persisted in the convalescent phase in one-fourth of cases.
Authors: Samer R Khan; Anna Vanoverschelde; Lies Lahousse; Robin P Peeters; P Martin van Hagen; Guy Brusselle; Layal Chaker; Virgil A S H Dalm Journal: Front Immunol Date: 2022-06-02 Impact factor: 8.786
Authors: Tobias Welte; R Phillip Dellinger; Henning Ebelt; Miguel Ferrer; Steven M Opal; Mervyn Singer; Jean-Louis Vincent; Karl Werdan; Ignacio Martin-Loeches; Jordi Almirall; Antonio Artigas; Jose Ignacio Ayestarán; Sebastian Nuding; Ricard Ferrer; Gonzalo Sirgo Rodríguez; Manu Shankar-Hari; Francisco Álvarez-Lerma; Reimer Riessen; Josep-Maria Sirvent; Stefan Kluge; Kai Zacharowski; Juan Bonastre Mora; Harald Lapp; Gabriele Wöbker; Ute Achtzehn; David Brealey; Axel Kempa; Miguel Sánchez García; Jörg Brederlau; Matthias Kochanek; Henrik Peer Reschreiter; Matthew P Wise; Bernd H Belohradsky; Iris Bobenhausen; Benjamin Dälken; Patrick Dubovy; Patrick Langohr; Monika Mayer; Jörg Schüttrumpf; Andrea Wartenberg-Demand; Ulrike Wippermann; Daniele Wolf; Antoni Torres Journal: Intensive Care Med Date: 2018-04-09 Impact factor: 17.440
Authors: Mathias W Pletz; Andreas Vestergaard Jensen; Christina Bahrs; Claudia Davenport; Jan Rupp; Martin Witzenrath; Grit Barten-Neiner; Martin Kolditz; Sabine Dettmer; James D Chalmers; Daiana Stolz; Norbert Suttorp; Stefano Aliberti; Wolfgang M Kuebler; Gernot Rohde Journal: Respir Res Date: 2022-09-10
Authors: Mari C de la Torre; Pere Torán; Mateu Serra-Prat; Elisabet Palomera; Estel Güell; Ester Vendrell; Joan Carles Yébenes; Antoni Torres; Jordi Almirall Journal: BMJ Open Respir Res Date: 2016-11-28
Authors: William W Siljan; Jan C Holter; Ståle H Nymo; Einar Husebye; Thor Ueland; Lillemor Skattum; Vidar Bosnes; Peter Garred; Stig S Frøland; Tom E Mollnes; Pål Aukrust; Lars Heggelund Journal: Open Forum Infect Dis Date: 2018-01-05 Impact factor: 3.835