AIMS AND BACKGROUND: To improve understanding of the relationship between schistosome-related enteropathy and colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics of colonic schistosomiasis. MATERIALS AND METHODS: All cases of intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179 cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected for analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics were retrospectively evaluated. RESULTS: Of the 179 colonic schistosomiasis patients, 32 combined with colorectal cancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classified as 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%), and 3 IIc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19 patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 well- differentiated adenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma. The pathological findings suggest colorectal malignancy with deposited schistosome ova. CONCLUSIONS: Chronic schistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.
AIMS AND BACKGROUND: To improve understanding of the relationship between schistosome-related enteropathy and colorectal carcinoma with particular focus on endoscopic findings and clinicopathological characteristics of colonic schistosomiasis. MATERIALS AND METHODS: All cases of intestinal schistosomiasis diagnosed at West China Hospital, Chengdu, China, between October 2006 and October 2012 were included in this study. A total of 179 cases of colonic schistosomiasis diagnosed through colonoscopy and pathological examinations were collected for analysis and the demographics, symptoms, endoscopic findings and clinicopathological characteristics were retrospectively evaluated. RESULTS: Of the 179 colonic schistosomiasispatients, 32 combined with colorectal cancer (CRC) were found, between the ages of 44 and 85 years (24 males, 75%). These 32 lesions were classified as 12 endophytic/ulcerative (37.5%), 10 exophytic/fungating (31.2%), 4 annular (12.5%), 3 giant polypus (9.4%), and 3 IIc (superficial depressed type) (9.4%). The segments of rectum and sigmoid colon were involved in 19 patients (59.4%) and 6 patients (18.8%), respectively. The histopathologic types were classified as follows: 30 well- differentiated adenocarcinomas, one mucinous adenocarcinoma and one poorly differentiated adenocarcinoma. The pathological findings suggest colorectal malignancy with deposited schistosome ova. CONCLUSIONS: Chronic schistosomal infestation has a probable etiological role in promoting genesis of colorectal neoplasms.
Authors: Hao Feng; Ai-Guo Lu; Xue-Wei Zhao; Ding-Pei Han; Jing-Kun Zhao; Lei Shi; Tobias S Schiergens; Serene M L Lee; Wen-Peng Zhang; Wolfgang E Thasler Journal: World J Gastroenterol Date: 2015-06-21 Impact factor: 5.742
Authors: Gustavo Fernandes Godoy Almeida; Filipe Wanick Sarinho; Paula Carvalho de Abreu E Lima; Joao Bosco Oliveira Filho; Maxwell Alex de Lima Moura; Lais Neares Barbosa Ribeiro; Bruno Rolim de Brito; Mariana Montenegro de Melo Lira; Marcelo do Rego Maciel Souto Maior; Ana Lucia Coutinho Domingues Journal: J Glob Oncol Date: 2016-08-24
Authors: Ayesiga M Herman; Alfred Kishe; Heri Babu; Hilary Shilanaiman; Murad Tarmohamed; Jay Lodhia; Patrick Amsi; Jeremia Pyuza; Alex Mremi; Amos Mwasamwaja; Mramba Nyindo; Kondo Chilonga; David Msuya Journal: World J Surg Oncol Date: 2017-08-02 Impact factor: 2.754