Jayasree Hansda1, Joydeb Roychowdhury. 1. NRS Medical College, Kolkata, India ; C/O-Sri R C Hansda, 2/2 Krittibas Road (South), B-Zone, Durgapur, Burdwan, 713205 WB Kolkata, India.
Abstract
OBJECTIVES: Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss. MATERIALS AND METHODS: 53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study. RESULTS: Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level. CONCLUSION: This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss.
OBJECTIVES: Recently, it has been found that women who have thrombophilia have increased risk of fetal loss. This study was designed to corroborate the association of elevated factor VIII level, protein C and protein S deficiencies, and the presence of LAC in women with recurrent pregnancy loss. MATERIALS AND METHODS: 53 patients with history of two or more pregnancy losses and 47 healthy age-matched subjects with no history of pregnancy loss and who have delivered at least one term infant without any complication were enrolled into the study. RESULTS:Thrombophilic defect was present in 64.15 % of patients of study group. Protein S deficiency (50.94 %) was the most common thrombophilic defect observed. Spontaneous abortion (SA), preterm birth (PTB), and intrauterine growth retardation (IUGR) were the most important pregnancy complications observed. The strongest associations of pregnancy complications were observed with protein S deficiency (87.5 %) and with elevated factor VIII (66.66 %) level. CONCLUSION: This study observed strong association of thrombophilia with unexplained recurrent pregnancy loss.
Authors: L Robertson; O Wu; P Langhorne; S Twaddle; P Clark; G D O Lowe; I D Walker; M Greaves; I Brenkel; L Regan; I A Greer Journal: Br J Haematol Date: 2006-01 Impact factor: 6.998
Authors: Astrid Dossenbach-Glaninger; Michael van Trotsenburg; Walter Krugluger; Martin R Dossenbach; Christian Oberkanins; Johannes Huber; Pierre Hopmeier Journal: Thromb Haemost Date: 2004-04 Impact factor: 5.249
Authors: Maristella D'Uva; Pierpaolo Di Micco; Ida Strina; Antonio Ranieri; Carlo Alviggi; Antonio Mollo; Francesca Fabozzi; Lucia Cacciapuoti; Maria Teresa Scotto di Frega; Mariateresa Iannuzzo; Giuseppe De Placido Journal: Biologics Date: 2008-12