BACKGROUND: Short bowel syndrome (SBS) is still a life-threatening disease in both children and adults. Although the therapeutic options are improving, challenges still remain, and to overcome these challenges is a major focus of SBS research today. In order to simulate anatomical and physiological conditions similar to those in humans for research, porcine models of SBS are often used. Various approaches for generating SBS models have been described in the literature. METHODS/ RESULTS: In this work, we present a review of different types of porcine models of SBS and outline the differences between those models regarding types of animals, surgical procedures, monitoring, and methods of assessment. CONCLUSION: The aim of this study was to select the most suitable SBS model regarding the purpose of the research.
BACKGROUND:Short bowel syndrome (SBS) is still a life-threatening disease in both children and adults. Although the therapeutic options are improving, challenges still remain, and to overcome these challenges is a major focus of SBS research today. In order to simulate anatomical and physiological conditions similar to those in humans for research, porcine models of SBS are often used. Various approaches for generating SBS models have been described in the literature. METHODS/ RESULTS: In this work, we present a review of different types of porcine models of SBS and outline the differences between those models regarding types of animals, surgical procedures, monitoring, and methods of assessment. CONCLUSION: The aim of this study was to select the most suitable SBS model regarding the purpose of the research.
Authors: Per T Sangild; Denise M Ney; David L Sigalet; Andreas Vegge; Douglas Burrin Journal: Am J Physiol Gastrointest Liver Physiol Date: 2014-10-23 Impact factor: 4.052
Authors: K A Schall; K A Holoyda; C N Grant; D E Levin; E R Torres; A Maxwell; H A Pollack; R A Moats; M R Frey; A Darehzereshki; D Al Alam; C Lien; T C Grikscheit Journal: Am J Physiol Gastrointest Liver Physiol Date: 2015-06-18 Impact factor: 4.052
Authors: Savas Theodore Tsikis; Scott C Fligor; Jordan D Secor; Lumeng J Yu; Amy Pan; Greta Loring; Eric First; Arthur P Nedder; Robin M Grammer; Coral Rudie; Kathleen M Gura; Mark Puder Journal: J Surg Res Date: 2022-02-02 Impact factor: 2.417