| Literature DB >> 24080468 |
Marcin Ozarowski1, Przemyslaw L Mikolajczak2, Anna Bogacz3, Agnieszka Gryszczynska4, Malgorzata Kujawska5, Jadwiga Jodynis-Liebert6, Anna Piasecka7, Hanna Napieczynska8, Michał Szulc9, Radoslaw Kujawski10, Joanna Bartkowiak-Wieczorek11, Joanna Cichocka12, Teresa Bobkiewicz-Kozlowska13, Boguslaw Czerny14, Przemyslaw M Mrozikiewicz15.
Abstract
Rosmarinus officinalis L. leaf as part of a diet and medication can be a valuable proposal for the prevention and treatment of dementia. The aim of the study was to assess the effects of subchronic (28-fold) administration of a plant extract (RE) (200 mg/kg, p.o.) on behavioral and cognitive responses of rats linked with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity and their mRNA expression level in the hippocampus and frontal cortex. The passive avoidance test results showed that RE improved long-term memory in scopolamine-induced rats. The extract inhibited the AChE activity and showed a stimulatory effect on BuChE in both parts of rat brain. Moreover, RE produced a lower mRNA BuChE expression in the cortex and simultaneously an increase in the hippocampus. The study suggests that RE led to improved long-term memory in rats, which can be partially explained by its inhibition of AChE activity in rat brain.Entities:
Keywords: Acetylcholinesterase; Butyrylcholinesterase; Carnosic acid (PubChem CID: 65126); Carnosol (PubChem CID: 2579); Huperzine A (PubChem CID: 1253); Memory; Rat; Rosemary; Rosmarinic acid (PubChem CID: 5281792); Scopolamine hydrobromide (CID: 5184)
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Year: 2013 PMID： 24080468 DOI： 10.1016/j.fitote.2013.09.012
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882