| Literature DB >> 24080355 |
Sulamita da Silva Setubal1, Adriana Silva Pontes, Neriane Monteiro Nery, Jéssica Silva Félix Bastos, Onassis Boeri Castro, Weverson Luciano Pires, Kayena Delaix Zaqueo, Leonardo de Azevedo Calderon, Rodrigo Guerino Stábeli, Andreimar Martins Soares, Juliana Pavan Zuliani.
Abstract
The aim of the study was to evaluate the in vitro effects of Bothrops bilineata crude venom (BbV) on isolated human neutrophil function. We proved that BbV isn't toxic towards human neutrophils. During an incubation of human neutrophils with BbV hydrogen peroxide was produced. Moreover, BbV was able to stimulate neutrophil release of proinflammatory mediators such as IL-8 and IL-6 as well as PGE2 and NETs liberation. There is no data in the literature showing the effect of BbV on the production of IL-6 and IL-8 or NETs liberation by isolated human neutrophils. Taken together our results testify that BbV triggers relevant proinflammatory events in human neutrophils.Entities:
Keywords: Bothrops (Bothriopsis) bilineata venom; Cytokines; NETs; Neutrophils; Reactive oxygen species
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Year: 2013 PMID： 24080355 DOI： 10.1016/j.toxicon.2013.09.019
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033