Diana M Orbelo1, Joseph R Duffy2, Becky J Hughes Borst3, Dale Ekbom3, Nicolas E Maragos3. 1. Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota; Division of Speech Pathology, Department of Neurology, Mayo Clinic, Rochester, Minnesota. Electronic address: dmorbelo@gmail.com. 2. Division of Speech Pathology, Department of Neurology, Mayo Clinic, Rochester, Minnesota. 3. Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota.
Abstract
OBJECTIVES: To explore possible dose differences in average botulinum toxin (BTX) given to patients with adductor spasmodic dysphonia (ADSD) compared with patients with essential voice tremor (EVT). METHODS: A retrospective study compared the average BTX dose injected in equal doses to the thyroarytenoid (TA) muscles of 51 patients with ADSD with 52 patients with EVT. RESULTS: Those with ADSD received significantly higher total doses (6.80 ± 2.79 units) compared with those with EVT (5.02 ± 1.65 units). Dose at time of first injection, age at time of first injection, gender, year of first injection, and average time between injections were included in multivariate analysis but did not interact with total average dose findings. CONCLUSIONS: Patients with ADSD may need relatively higher doses of BTX injections to bilateral TA muscles compared with patients with EVT.
OBJECTIVES: To explore possible dose differences in average botulinum toxin (BTX) given to patients with adductor spasmodic dysphonia (ADSD) compared with patients with essential voice tremor (EVT). METHODS: A retrospective study compared the average BTX dose injected in equal doses to the thyroarytenoid (TA) muscles of 51 patients with ADSD with 52 patients with EVT. RESULTS: Those with ADSD received significantly higher total doses (6.80 ± 2.79 units) compared with those with EVT (5.02 ± 1.65 units). Dose at time of first injection, age at time of first injection, gender, year of first injection, and average time between injections were included in multivariate analysis but did not interact with total average dose findings. CONCLUSIONS:Patients with ADSD may need relatively higher doses of BTX injections to bilateral TA muscles compared with patients with EVT.
Authors: Priyesh N Patel; Edmond K Kabagambe; Jennifer C Starkweather; Matthew Keller; Vahram Gamsarian; Jane Lee; Vishnutheert Kulkarni; C Gaelyn Garrett; David O Francis Journal: JAMA Otolaryngol Head Neck Surg Date: 2018-04-01 Impact factor: 6.223
Authors: Priyesh N Patel; Edmond K Kabagambe; Jennifer C Starkweather; Matthew Keller; Zaki A Ahmed; Simone C Gruber; Jordan S Akins; C Gaelyn Garrett; David O Francis Journal: Laryngoscope Date: 2018-11-13 Impact factor: 3.325