Sang Yeob Seong1, Dong Woo Hyun2, Yoo Suk Kim3, Hyung-Ju Cho4, Jeung-Gweon Lee4, Joo-Heon Yoon4, Chang-Hoon Kim5. 1. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea. 2. Department of Otorhinolaryngology, Kang-Dong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea. 3. Department of Otorhinolaryngology, Ajou University College of Medicine, Suwon, Republic of Korea. 4. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea; The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. 5. Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea; The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: entman@yuhs.ac.
Abstract
OBJECTIVE: To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). MATERIAL AND METHODS: Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. RESULTS: The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. CONCLUSION: Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.
OBJECTIVE: To establish the clinical features and prognostic factors of sinonasal adenoid cystic carcinoma (ACC). MATERIAL AND METHODS: Thirty patients with histopathological diagnosis of sinonasal ACC who were treated at Severance Hospital between 1990 and 2010 were included in this retrospective chart review study. RESULTS: The 5-year disease-specific survival and disease-free survival rates were 75.3% and 37.2%, respectively. The maxillary sinus (63.3%) and nasal cavity (23.3%) were the most common sites of primary tumour. Most patients were diagnosed with advanced-stage (III/IV) disease (80.0%) and had undergone surgery and postoperative radiotherapy (70.0%). The most common histopathological subtype was cribriform type (40.9%). Local recurrence rate and distant metastasis rates were 26.7% and 23.3%, respectively. The mean time from primary treatment to recurrence was 44.5 months. Sinonasal ACC patients with stage IV and T4 disease had significantly worse survival than those with low stage and T disease. Patients with local recurrence had worse disease-specific survival than those with distant recurrence. Distant metastasis was associated with disease-free survival but not disease-specific survival. CONCLUSION: Despite the frequent occurrence of distant metastasis, early diagnosis and effective local control seemed to be the most important factors influencing the survival of sinonasal ACC.
Authors: T Schneider; A Strehl; C Linz; R Brands; S Hartmann; F Beckford; A Rosenwald; A C Kübler; U D A Müller-Richter Journal: Clin Oral Investig Date: 2015-08-06 Impact factor: 3.573