| Literature DB >> 24079664 |
Ludger A Wessjohann1, Günther O Scheid, Uwe Eichelberger, Sumaira Umbreen.
Abstract
A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.Entities:
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Year: 2013 PMID： 24079664 DOI： 10.1021/jo401355r
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354