PURPOSE: Lung transplantation (LTx) is an established therapy for end-stage lung failure. However, in Japan, the donor organ shortage is extremely severe compared with other developed countries, because of the strict Japanese Organ Transplantation Law. To maximize LTx opportunities in Japan, we have established a special donor evaluation and management system termed the medical consultant (MC) system. METHODS: Data from 171 lung donor candidates registered in Japan from May 1998 to May 2012 were obtained and investigated in a retrospective manner. The candidates were separated into the non-MC-intervened and MC-intervened groups, and then data regarding the PaO2/FiO2 ratio, donation rate and organ survival rate were analyzed and compared between the groups. RESULTS: The PaO2/FiO2 ratio of the MC-intervened group was ameliorated from the time of first brain death diagnosis to organ harvest. Although the base condition of the MC-intervened group was significantly worse than that of the non-MC-intervened group, the donation rates showed no significant difference (0.64 and 0.66, respectively; p = 0.89). There was a difference in the organ survival rate between the non-MC and MC-intervened groups (5-year survival rates of 67.2 and 88.3 %, respectively; p = 0.16). CONCLUSION: The MC system used for organ donor evaluation and management in Japan has achieved acceptable interim results.
PURPOSE: Lung transplantation (LTx) is an established therapy for end-stage lung failure. However, in Japan, the donor organ shortage is extremely severe compared with other developed countries, because of the strict Japanese Organ Transplantation Law. To maximize LTx opportunities in Japan, we have established a special donor evaluation and management system termed the medical consultant (MC) system. METHODS: Data from 171 lung donor candidates registered in Japan from May 1998 to May 2012 were obtained and investigated in a retrospective manner. The candidates were separated into the non-MC-intervened and MC-intervened groups, and then data regarding the PaO2/FiO2 ratio, donation rate and organ survival rate were analyzed and compared between the groups. RESULTS: The PaO2/FiO2 ratio of the MC-intervened group was ameliorated from the time of first brain death diagnosis to organ harvest. Although the base condition of the MC-intervened group was significantly worse than that of the non-MC-intervened group, the donation rates showed no significant difference (0.64 and 0.66, respectively; p = 0.89). There was a difference in the organ survival rate between the non-MC and MC-intervened groups (5-year survival rates of 67.2 and 88.3 %, respectively; p = 0.16). CONCLUSION: The MC system used for organ donor evaluation and management in Japan has achieved acceptable interim results.
Authors: Marc de Perrot; Gregory I Snell; Wayne D Babcock; Bryan F Meyers; Glenda Patterson; Tony N Hodges; Shaf Keshavjee Journal: J Heart Lung Transplant Date: 2004-10 Impact factor: 10.247
Authors: Jacqueline M Smits; George D Nossent; Erwin de Vries; Axel Rahmel; Bruno Meiser; Martin Strueber; Jens Gottlieb Journal: J Heart Lung Transplant Date: 2010-09-20 Impact factor: 10.247
Authors: Phil Botha; Dipesh Trivedi; Christopher J Weir; Cait P Searl; Paul A Corris; John H Dark; Stephan V B Schueler Journal: J Thorac Cardiovasc Surg Date: 2006-05 Impact factor: 5.209
Authors: Jose J P Camargo; Klaus L Irion; Edson Marchiori; Bruno Hochhegger; Nelson S Porto; Beatriz G Moraes; Gisela Meyer; Marlova Caramori; John A Holemans Journal: Pediatr Transplant Date: 2008-10-09