Literature DB >> 24077764

Going Green: The Role of the Green Tea Component EGCG in Chemoprevention.

Laura Schramm1.   

Abstract

Tea is one of the most consumed beverages worldwide, and green tea is the least processed from the buds of the Camellia sinensis plant. The most abundant component of green tea is (-)-epigallocatechin-3-gallate (EGCG), which has been the focus of many cell culture, animal and clinical trials, revealing that EGCG possesses antiproliferative, antimutagenic, antioxidant, antibacterial, antiviral and chemopreventive effects. In this review we briefly summarize the mechanism of action(s) of the green tea component EGCG, highlighting recent advances in the epigenetic regulation by EGCG. Additionally, we provide an overview of mouse chemoprevention studies and EGCG chemoprevention clinical trials.

Entities:  

Keywords:  Cancer; Chemoprevention; EGCG; Green tea

Year:  2013        PMID： 24077764      PMCID： PMC3783360          DOI： 10.4172/2157-2518.1000142

Source DB:  PubMed          Journal:  J Carcinog Mutagen


  121 in total

Review 1.  Medicinal benefits of green tea: Part I. Review of noncancer health benefits.

Authors:  Raymond Cooper; D James Morré; Dorothy M Morré
Journal:  J Altern Complement Med       Date:  2005-06       Impact factor: 2.579

2.  Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate.

Authors:  M Liberto; D Cobrinik
Journal:  Cancer Lett       Date:  2000-06-30       Impact factor: 8.679

3.  Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.

Authors:  Tharakeswari Selvakumar; Alison Gjidoda; Stacy L Hovde; R William Henry
Journal:  J Biol Chem       Date:  2012-01-04       Impact factor: 5.157

Review 4.  Prostate cancer chemoprevention by green tea.

Authors:  S Gupta; N Ahmad; H Mukhtar
Journal:  Semin Urol Oncol       Date:  1999-05

5.  Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study.

Authors:  Gong Yang; Wei Zheng; Yong-Bing Xiang; Jing Gao; Hong-Lan Li; Xianglan Zhang; Yu-Tang Gao; Xiao-Ou Shu
Journal:  Carcinogenesis       Date:  2011-08-19       Impact factor: 4.944

6.  Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study.

Authors:  Saverio Bettuzzi; Maurizio Brausi; Federica Rizzi; Giovanni Castagnetti; Giancarlo Peracchia; Arnaldo Corti
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

Review 7.  Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view.

Authors:  S Bettuzzi; F Rizzi; L Belloni
Journal:  Pol J Vet Sci       Date:  2007       Impact factor: 0.821

Review 8.  Beneficial effects of green tea--a review.

Authors:  Carmen Cabrera; Reyes Artacho; Rafael Giménez
Journal:  J Am Coll Nutr       Date:  2006-04       Impact factor: 3.169

9.  Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study.

Authors:  Masahito Shimizu; Yasushi Fukutomi; Mitsuo Ninomiya; Kazuo Nagura; Tomohiro Kato; Hiroshi Araki; Masami Suganuma; Hirota Fujiki; Hisataka Moriwaki
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-11       Impact factor: 4.254

Review 10.  Green tea and tea polyphenols in cancer prevention.

Authors:  Di Chen; Kenyon G Daniel; Deborah J Kuhn; Aslamuzzaman Kazi; Mohammad Bhuiyan; Lianhai Li; Zhigang Wang; Sheng Biao Wan; Wai Har Lam; Tak Hang Chan; Q Ping Dou
Journal:  Front Biosci       Date:  2004-09-01
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  23 in total

Review 1.  Green tea compounds in breast cancer prevention and treatment.

Authors:  Min-Jing Li; Yan-Cun Yin; Jiao Wang; Yang-Fu Jiang
Journal:  World J Clin Oncol       Date:  2014-08-10

2.  Gender Specific Differences in RNA Polymerase III Transcription.

Authors:  N Diette; J Koo; S Cabarcas-Petroski; L Schramm
Journal:  J Carcinog Mutagen       Date:  2016-01-29

3.  Resveratrol mediates cell cycle arrest and cell death in human esophageal squamous cell carcinoma by directly targeting the EGFR signaling pathway.

Authors:  Zixuan Jin; Wei Feng; Ying Ji; Longyu Jin
Journal:  Oncol Lett       Date:  2016-11-17       Impact factor: 2.967

Review 4.  Green Tea Epigallocatechin-3-Gallate Regulates Autophagy in Male and Female Reproductive Cancer.

Authors:  Sze Wan Hung; Yiran Li; Xiaoyan Chen; Kai On Chu; Yiwei Zhao; Yingyu Liu; Xi Guo; Gene Chi-Wai Man; Chi Chiu Wang
Journal:  Front Pharmacol       Date:  2022-07-04       Impact factor: 5.988

5.  Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1.

Authors:  Kewei Zhu; Wanchun Wang
Journal:  Tumour Biol       Date:  2015-10-24

6.  EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT.

Authors:  Yilixiati Xiaokaiti; Haoming Wu; Ya Chen; Haopeng Yang; Jianhui Duan; Xin Li; Yan Pan; Lu Tie; Liangren Zhang; Xuejun Li
Journal:  Sci Rep       Date:  2015-07-16       Impact factor: 4.379

Review 7.  Implications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling Pathway.

Authors:  Arshad H Rahmani; Fahad M Al Shabrmi; Khaled S Allemailem; Salah M Aly; Masood A Khan
Journal:  Biomed Res Int       Date:  2015-04-21       Impact factor: 3.411

8.  Construction of a SSR-based genetic map and identification of QTLs for catechins content in tea plant (Camellia sinensis).

Authors:  Jian-Qiang Ma; Ming-Zhe Yao; Chun-Lei Ma; Xin-Chao Wang; Ji-Qiang Jin; Xue-Min Wang; Liang Chen
Journal:  PLoS One       Date:  2014-03-27       Impact factor: 3.240

9.  Autophagy inhibition contributes to the synergistic interaction between EGCG and doxorubicin to kill the hepatoma Hep3B cells.

Authors:  Li Chen; Hui-Lan Ye; Guo Zhang; Wen-Min Yao; Xing-Zhou Chen; Fa-Can Zhang; Gang Liang
Journal:  PLoS One       Date:  2014-01-21       Impact factor: 3.240

10.  Iron-induced parafibrin formation in tumors fosters immune evasion.

Authors:  Boguslaw Lipinski
Journal:  Oncoimmunology       Date:  2014-04-25       Impact factor: 8.110
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