OBJECTIVE: To examine the independent association between heart rate variability (HRV) and cognitive performance, in a nationally representative population study of older adults. METHODS: Cross-sectional analysis of wave 1 data from the Irish longitudinal study on ageing (TILDA) was performed. A subset of 4,763 participants who underwent ECG recording during resting and paced breathing periods were used for the analysis. HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment (MOCA) score. Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index, after adjustment for covariates. RESULTS: The mean age was 61.7 ± 8.3 years and 2,618 (55 %) were female. Lower quintiles of SDNN (P = 0.01-paced), LF (P = 0.001-paced), and LF:HF ratio (P = 0.049-paced) were significantly associated with lower MOCA scores (during both recording periods), independent of confounders. Sub-domains of MOCA responsible for the relationship were predominantly memory recall and language. INTERPRETATION: Reduced HRV is significantly associated with lower cognitive performance at a population level in people aged 50 and older. This further strengthens the relationship between autonomic dysfunction and cognitive disorders.
OBJECTIVE: To examine the independent association between heart rate variability (HRV) and cognitive performance, in a nationally representative population study of older adults. METHODS: Cross-sectional analysis of wave 1 data from the Irish longitudinal study on ageing (TILDA) was performed. A subset of 4,763 participants who underwent ECG recording during resting and paced breathing periods were used for the analysis. HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment (MOCA) score. Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index, after adjustment for covariates. RESULTS: The mean age was 61.7 ± 8.3 years and 2,618 (55 %) were female. Lower quintiles of SDNN (P = 0.01-paced), LF (P = 0.001-paced), and LF:HF ratio (P = 0.049-paced) were significantly associated with lower MOCA scores (during both recording periods), independent of confounders. Sub-domains of MOCA responsible for the relationship were predominantly memory recall and language. INTERPRETATION: Reduced HRV is significantly associated with lower cognitive performance at a population level in people aged 50 and older. This further strengthens the relationship between autonomic dysfunction and cognitive disorders.
Authors: Julian N Trollor; Evelyn Smith; Emmeline Agars; Stacey A Kuan; Bernhard T Baune; Lesley Campbell; Katherine Samaras; John Crawford; Ora Lux; Nicole A Kochan; Henry Brodaty; Perminder Sachdev Journal: Age (Dordr) Date: 2011-08-19
Authors: Zaldy S Tan; Alexa S Beiser; Caroline S Fox; Rhoda Au; Jayandra J Himali; Stephanie Debette; Charles Decarli; Ramachandran S Vasan; Philip A Wolf; Sudha Seshadri Journal: Diabetes Care Date: 2011-06-16 Impact factor: 19.112
Authors: Helena Dolphin; Tim Dukelow; Ciaran Finucane; Sean Commins; Paul McElwaine; Sean P Kennelly Journal: Front Neurosci Date: 2022-06-16 Impact factor: 5.152
Authors: Adina Zeki Al Hazzouri; Tali Elfassy; Mercedes R Carnethon; Donald M Lloyd-Jones; Kristine Yaffe Journal: Am J Hypertens Date: 2017-12-08 Impact factor: 3.080
Authors: Kathi L Heffner; Maria M Quiñones; Autumn M Gallegos; Hugh F Crean; Feng Lin; Julie A Suhr Journal: Aging Ment Health Date: 2021-03-30 Impact factor: 3.514
Authors: Lydia Brown; Alora A Rando; Kristina Eichel; Nicholas T Van Dam; Christopher M Celano; Jeff C Huffman; Meg E Morris Journal: Psychosom Med Date: 2021 Jul-Aug 01 Impact factor: 4.312
Authors: Ridwan M Alomri; Gerard A Kennedy; Siraj Omar Wali; Faris Alhejaili; Stephen R Robinson Journal: Sci Rep Date: 2021-06-07 Impact factor: 4.379