BACKGROUND: Dental infections are frequent and have recently been implicated as a possible risk factor for Alzheimer's disease (AD). Despite a lack of studies investigating orofacial pain in this patient group, dental conditions are known to be a potential cause of pain and to affect quality of life and disease progression. OBJECTIVES: To evaluate oral status, mandibular function and orofacial pain in patients with mild AD versus healthy subjects matched for age and gender. METHODS: Twenty-nine patients and 30 control subjects were evaluated. The protocol comprised a clinical questionnaire and dental exam, research diagnostic criteria for temporomandibular disorders, the McGill Pain Questionnaire, the decayed, missing, and filled teeth index, and included a full periodontal evaluation. AD signs and symptoms as well as associated factors were evaluated by a trained neurologist. RESULTS: A higher prevalence of orofacial pain (20.7%, p < 0.001), articular abnormalities in temporomandibular joints (p < 0.05), and periodontal infections (p = 0.002) was observed in the study group compared to the control group. CONCLUSION: Orofacial pain and periodontal infections were more frequent in patients with mild AD than in healthy subjects. Orofacial pain screening and dental and oral exams should be routinely performed in AD patients in order to identify pathological conditions that need treatment thus improving quality of life compromised due to dementia.
BACKGROUND:Dental infections are frequent and have recently been implicated as a possible risk factor for Alzheimer's disease (AD). Despite a lack of studies investigating orofacial pain in this patient group, dental conditions are known to be a potential cause of pain and to affect quality of life and disease progression. OBJECTIVES: To evaluate oral status, mandibular function and orofacial pain in patients with mild AD versus healthy subjects matched for age and gender. METHODS: Twenty-nine patients and 30 control subjects were evaluated. The protocol comprised a clinical questionnaire and dental exam, research diagnostic criteria for temporomandibular disorders, the McGill Pain Questionnaire, the decayed, missing, and filled teeth index, and included a full periodontal evaluation. AD signs and symptoms as well as associated factors were evaluated by a trained neurologist. RESULTS: A higher prevalence of orofacial pain (20.7%, p < 0.001), articular abnormalities in temporomandibular joints (p < 0.05), and periodontal infections (p = 0.002) was observed in the study group compared to the control group. CONCLUSION:Orofacial pain and periodontal infections were more frequent in patients with mild AD than in healthy subjects. Orofacial pain screening and dental and oral exams should be routinely performed in ADpatients in order to identify pathological conditions that need treatment thus improving quality of life compromised due to dementia.
Authors: K S Ma; H Hasturk; I Carreras; A Dedeoglu; J J Veeravalli; J Y Huang; A Kantarci; J C Wei Journal: J Dent Res Date: 2021-10-13 Impact factor: 6.116
Authors: B Daly; A Thompsell; J Sharpling; Y M Rooney; L Hillman; K L Wanyonyi; S White; J E Gallagher Journal: Br Dent J Date: 2017-12-01 Impact factor: 1.626
Authors: Suzanne Delwel; Tarik T Binnekade; Roberto S G M Perez; Cees M P M Hertogh; Erik J A Scherder; Frank Lobbezoo Journal: Clin Oral Investig Date: 2016-09-08 Impact factor: 3.573
Authors: Suzanne Delwel; Tarik T Binnekade; Roberto S G M Perez; Cees M P M Hertogh; Erik J A Scherder; Frank Lobbezoo Journal: Clin Oral Investig Date: 2017-11-15 Impact factor: 3.573
Authors: Liza J M van de Rijt; Roxane A F Weijenberg; Alexandra R Feast; Victoria Vickerstaff; Frank Lobbezoo; Elizabeth L Sampson Journal: BMC Geriatr Date: 2018-05-23 Impact factor: 3.921