Literature DB >> 24077114

Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect.

Dechun Liu1, Yanbin Chen2, Xiaoshan Feng2, Miao Deng2, Gangqiang Xie2, Jianguang Wang2, Like Zhang2, Qipeng Liu2, Pengfei Yuan2.   

Abstract

Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer-gemcitabine and polymer-doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Doxorubicin; Drug delivery; Gemcitabine; Micelles; Polymer conjugates

Mesh：

Substances：

Year:  2013        PMID： 24077114     DOI： 10.1016/j.colsurfb.2013.08.010

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


  10 in total

1.  Development of Liposomal Gemcitabine with High Drug Loading Capacity.

Authors:  Hassan Tamam; Jinho Park; Hytham H Gadalla; Andrea R Masters; Jelan A Abdel-Aleem; Sayed I Abdelrahman; Aly A Abdelrahman; L Tiffany Lyle; Yoon Yeo
Journal:  Mol Pharm       Date:  2019-06-14       Impact factor: 4.939

2.  Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids.

Authors:  John D Schneible; Ashlyn T Young; M A Daniele; S Menegatti
Journal:  Pharm Res       Date:  2020-07-13       Impact factor: 4.200

3.  Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells.

Authors:  Rahul Nahire; Manas K Haldar; Shirshendu Paul; Avinash H Ambre; Varsha Meghnani; Buddhadev Layek; Kalpana S Katti; Kara N Gange; Jagdish Singh; Kausik Sarkar; Sanku Mallik
Journal:  Biomaterials       Date:  2014-05-05       Impact factor: 12.479

4.  Tailoring the properties of mPEG-PLLA nanoparticles for better encapsulation and tuned release of the hydrophilic anticancer drug.

Authors:  Sachin S Surwase; Neha M Munot; Bhaskar B Idage; Susheela B Idage
Journal:  Drug Deliv Transl Res       Date:  2017-06       Impact factor: 4.617

5.  Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics.

Authors:  John D Schneible; Kaihang Shi; Ashlyn T Young; Srivatsan Ramesh; Nanfei He; Clay E Dowdey; Jean Marie Dubnansky; Radina L Lilova; Wei Gao; Erik Santiso; Michael Daniele; Stefano Menegatti
Journal:  J Mater Chem B       Date:  2020-05-06       Impact factor: 6.331

6.  Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy.

Authors:  Aniket Gad; Janel Kydd; Brandon Piel; Prakash Rai
Journal:  Int J Nanomed Nanosurg       Date:  2016-07-04

Review 7.  Mechanisms Underlying Cytotoxicity Induced by Engineered Nanomaterials: A Review of In Vitro Studies.

Authors:  Daniele R Nogueira; Montserrat Mitjans; Clarice M B Rolim; M Pilar Vinardell
Journal:  Nanomaterials (Basel)       Date:  2014-06-12       Impact factor: 5.076

8.  Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine.

Authors:  Ty Santiago; Rebecca Sinnott DeVaux; Katarzyna Kurzatkowska; Ricardo Espinal; Jason I Herschkowitz; Maria Hepel
Journal:  Int J Nanomedicine       Date:  2017-10-24

Review 9.  Polymeric Nanoparticle Delivery of Combination Therapy with Synergistic Effects in Ovarian Cancer.

Authors:  Shani L Levit; Christina Tang
Journal:  Nanomaterials (Basel)       Date:  2021-04-20       Impact factor: 5.076

10.  Schedule dependent synergy of gemcitabine and doxorubicin: Improvement of in vitro efficacy and lack of in vitro-in vivo correlation.

Authors:  Douglas R Vogus; Anusha Pusuluri; Renwei Chen; Samir Mitragotri
Journal:  Bioeng Transl Med       Date:  2018-01-19
  10 in total

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