| Literature DB >> 24076173 |
Joseph J Topczewski1, Alexander M Lodge, Sumana N Yasapala, Maurice K Payne, Pedrom M Keshavarzi, Daniel M Quinn.
Abstract
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.Entities:
Keywords: 2-Methoxypyridinium compounds; Acetylcholinesterase; Reversible inhibition
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Year: 2013 PMID： 24076173 DOI： 10.1016/j.bmcl.2013.09.008
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823