BACKGROUND: The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored. METHODS: 1397 colorectal cancer patients participating in two cancer cohorts (ESTHER II and VERDI) and in a population-based case-control study (DACHS) were followed for 5 years. Unadjusted and adjusted hazard ratios for all-cause mortality (469 events) and CRC-specific mortality (336 events) were estimated for VDR variants rs731236 (TaqI), rs2228570 (FokI), rs11568820 (Cdx2), and rs1989969 (VDR-5132). RESULTS: No association was found between VDR polymorphism and CRC specific and all-cause mortality. Adjusted hazard ratios ranged from 0.79 (95% CI 0.57-1.12) to 1.14 (95% CI 0.89-1.46) for CRC-specific mortality and from 0.89 (95% CI 0.67-1.18) to 1.22 (95% CI 0.99-1.50) for all-cause mortality. All 95% confidence intervals included the null value. CONCLUSIONS: Our findings do not support the hypothesis that the common VDR gene variants investigated in this study are of clinical relevance with respect to CRC prognosis.
BACKGROUND: The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored. METHODS: 1397 colorectal cancerpatients participating in two cancer cohorts (ESTHER II and VERDI) and in a population-based case-control study (DACHS) were followed for 5 years. Unadjusted and adjusted hazard ratios for all-cause mortality (469 events) and CRC-specific mortality (336 events) were estimated for VDR variants rs731236 (TaqI), rs2228570 (FokI), rs11568820 (Cdx2), and rs1989969 (VDR-5132). RESULTS: No association was found between VDR polymorphism and CRC specific and all-cause mortality. Adjusted hazard ratios ranged from 0.79 (95% CI 0.57-1.12) to 1.14 (95% CI 0.89-1.46) for CRC-specific mortality and from 0.89 (95% CI 0.67-1.18) to 1.22 (95% CI 0.99-1.50) for all-cause mortality. All 95% confidence intervals included the null value. CONCLUSIONS: Our findings do not support the hypothesis that the common VDR gene variants investigated in this study are of clinical relevance with respect to CRC prognosis.
Authors: Khayal A Alkhayal; Zainab H Awadalia; Mansoor-Ali Vaali-Mohammed; Omar A Al Obeed; Alanoud Al Wesaimer; Rabih Halwani; Ahmed M Zubaidi; Zahid Khan; Maha-Hamadien Abdulla Journal: PLoS One Date: 2016-06-16 Impact factor: 3.240
Authors: P G Vaughan-Shaw; F O'Sullivan; S M Farrington; E Theodoratou; H Campbell; M G Dunlop; L Zgaga Journal: Br J Cancer Date: 2017-03-16 Impact factor: 7.640
Authors: Izabela Laczmanska; Lukasz Laczmanski; Marek Bebenek; Pawel Karpinski; Halina Czemarmazowicz; David Ramsey; Andrzej Milewicz; Maria M Sasiadek Journal: Tumour Biol Date: 2014-09-07
Authors: Yun Zhu; Peizhong Peter Wang; Guangju Zhai; Bharati Bapat; Sevtap Savas; Jennifer R Woodrow; Ishor Sharma; Yuming Li; Xin Zhou; Ning Yang; Peter T Campbell; Elizabeth Dicks; Patrick S Parfrey; John R Mclaughlin Journal: Br J Cancer Date: 2017-08-01 Impact factor: 7.640
Authors: Aoife Doherty; Yelena Kernogitski; Alexander M Kulminski; João Pedro de Magalhães Journal: Aging (Albany NY) Date: 2017-10-20 Impact factor: 5.682