Fan Li1, Guifeng Li, Haikun Hu, Renkai Liu, Jianwei Chen, Shujuan Zou. 1. Postgraduate student, State Key Laboratory of Oral Diseases and Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Abstract
INTRODUCTION: The aim of this study was to investigate the effect of parathyroid hormone injection on experimental tooth movement in rats. METHODS: Sixty male Wistar rats were randomly divided into 2 groups. Their maxillary right first molars were moved mesially with nickel-titanium closed-coil springs. The experimental group received daily subcutaneous injections of parathyroid hormone at a dose of 4 μg per 100 g of body weight for 12 days, and the control group received vehicle injections. The results were evaluated by intraoral measurements and by hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry staining. RESULTS: The tooth movement and osteoclast numbers were significantly increased in the parathyroid hormone group compared with the control group. The expressions of receptor activator of nuclear factor kappa B ligand and insulin-like growth factor-I were significantly stimulated in the parathyroid hormone group. CONCLUSIONS: The data suggest that short-term parathyroid hormone injection might be a potential method for accelerating orthodontic tooth movement by increasing the alveolar bone turnover rate.
INTRODUCTION: The aim of this study was to investigate the effect of parathyroid hormone injection on experimental tooth movement in rats. METHODS: Sixty male Wistar rats were randomly divided into 2 groups. Their maxillary right first molars were moved mesially with nickel-titanium closed-coil springs. The experimental group received daily subcutaneous injections of parathyroid hormone at a dose of 4 μg per 100 g of body weight for 12 days, and the control group received vehicle injections. The results were evaluated by intraoral measurements and by hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry staining. RESULTS: The tooth movement and osteoclast numbers were significantly increased in the parathyroid hormone group compared with the control group. The expressions of receptor activator of nuclear factor kappa B ligand and insulin-like growth factor-I were significantly stimulated in the parathyroid hormone group. CONCLUSIONS: The data suggest that short-term parathyroid hormone injection might be a potential method for accelerating orthodontic tooth movement by increasing the alveolar bone turnover rate.
Authors: Nunzio Cirulli; Alessio Danilo Inchingolo; Assunta Patano; Sabino Ceci; Grazia Marinelli; Giuseppina Malcangi; Giovanni Coloccia; Valentina Montenegro; Chiara Di Pede; Anna Maria Ciocia; Giuseppe Barile; Antonio Mancini; Giulia Palmieri; Daniela Azzollini; Biagio Rapone; Ludovica Nucci; Ioana Roxana Bordea; Antonio Scarano; Felice Lorusso; Gianluca Martino Tartaglia; Cinzia Maspero; Manuel Nuzzolese; Filippo Cardarelli; Daniela Di Venere; Angelo Michele Inchingolo; Gianna Dipalma; Francesco Inchingolo Journal: Int J Environ Res Public Health Date: 2022-06-17 Impact factor: 4.614
Authors: Fan Yang; Xu Xia Wang; Dan Ma; Qun Cui; De Hua Zheng; Xiao Can Liu; Jun Zhang Journal: Drug Des Devel Ther Date: 2019-11-25 Impact factor: 4.162