Holger Hövel1, Eino Partanen2, Minna Huotilainen3, Magnus Lindgren4, Ingmar Rosén5, Vineta Fellman6. 1. Department of Clinical Sciences, Pediatrics, Lund University and Lund University Hospital, Lund, Sweden. Electronic address: holger.hovel@med.lu.se. 2. Cognitive Brain Research Unit, Cognitive Science, Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland; Finnish Centre of Excellence in Interdisciplinary Music Research, University of Jyväskylä, Helsinki, Finland. 3. Cognitive Brain Research Unit, Cognitive Science, Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland; Finnish Centre of Excellence in Interdisciplinary Music Research, University of Jyväskylä, Helsinki, Finland; Finnish Institute of Occupational Health, Helsinki, Finland. 4. Department of Psychology, Lund University, Lund, Sweden. 5. Department of Clinical Sciences, Neurophysiology, Lund University and Lund University Hospital, Lund, Sweden. 6. Department of Clinical Sciences, Pediatrics, Lund University and Lund University Hospital, Lund, Sweden; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Abstract
OBJECTIVE: To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4 ± 1.9 gestational weeks, n=70) with a high risk of cognitive dysfunction. METHODS: We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration). RESULTS: The P1 and N2 latencies were inversely correlated to age (50-63 months) both in VP (r=-0.451, p<0.001, and r=-0.305, p=0.01, respectively) and term born controls (TC; n=15). VP children had smaller P1 than near-term (n=12) or TC (1.70 ± 0.17 μV vs 2.68 ± 0.41 and 2.92 ± 0.43, respectively; p<0.05). Mismatch negativity response did not differ between groups. CONCLUSIONS: Our data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5 years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children. SIGNIFICANCE: In ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits.
OBJECTIVE: To assess auditory event-related potentials at preschool age in children born very preterm (VP, 27.4 ± 1.9 gestational weeks, n=70) with a high risk of cognitive dysfunction. METHODS: We used an oddball paradigm consisting of a standard tone randomly replaced by one of three infrequent deviants (differing in frequency, sound direction or duration). RESULTS: The P1 and N2 latencies were inversely correlated to age (50-63 months) both in VP (r=-0.451, p<0.001, and r=-0.305, p=0.01, respectively) and term born controls (TC; n=15). VP children had smaller P1 than near-term (n=12) or TC (1.70 ± 0.17 μV vs 2.68 ± 0.41 and 2.92 ± 0.43, respectively; p<0.05). Mismatch negativity response did not differ between groups. CONCLUSIONS: Our data suggest a fast maturation of P1 and N2 responses with fast decrease in P1 and N2 latencies around the age of 5 years. Mismatch negativity response does not seem to be a robust measure for defining abnormalities in VP children. SIGNIFICANCE: In ERP studies in preschool children, even small, non-significant group differences in age at recording should be corrected for. Very preterm born children at preschool age have aERP patterns as earlier described in full-term born children with cognitive deficits.
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