OBJECTIVE: To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. METHODS: An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine. RESULTS: All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism. CONCLUSIONS: A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.
OBJECTIVE: To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects. METHODS: An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine. RESULTS: All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism. CONCLUSIONS:A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.
Authors: Mariana Torres-Piedra; Mario Figueroa; Oswaldo Hernández-Abreu; Maximiliano Ibarra-Barajas; Gabriel Navarrete-Vázquez; Samuel Estrada-Soto Journal: Bioorg Med Chem Date: 2010-11-04 Impact factor: 3.641
Authors: Ashok Jadhav; Wenbin Liang; Peter C Papageorgiou; Ahmed Shoker; Selliah C Kanthan; John Balsevich; Andrew S Levy; Scott Heximer; Peter H Backx; Venkat Gopalakrishnan Journal: J Pharmacol Exp Ther Date: 2013-03-26 Impact factor: 4.030
Authors: Mohammed S Hifnawy; Mahmoud A Aboseada; Hossam M Hassan; Asmaa M AboulMagd; Adel F Tohamy; Samraa H Abdel-Kawi; Mostafa E Rateb; El Moataz Bellah El Naggar; Miaomiao Liu; Ronald J Quinn; Hani A Alhadrami; Usama Ramadan Abdelmohsen Journal: Metabolites Date: 2020-01-11