PURPOSE: [(11)C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [(11)C]FLB 457 in healthy human subjects. METHODS: Whole-body images were acquired for 2 h after an injection of [(11)C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software. RESULTS: Organs with the longest residence time were the liver, lungs, and brain. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [(11)C]FLB 457 is 5.9 μSv/MBq, similar to those of other (11)C-labeled tracers. CONCLUSIONS: This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended-dose guidelines in the USA and Europe.
PURPOSE: [(11)C]FLB 457, a radioligand with very high affinity and selectivity for dopamine D2/3 receptors, is used to measure receptor binding in extrastriatal regions showing low density of the receptors. The purpose of this study was to estimate the whole-body biodistribution of radioactivity and the radiation absorbed doses to organs after intravenous injection of [(11)C]FLB 457 in healthy human subjects. METHODS: Whole-body images were acquired for 2 h after an injection of [(11)C]FLB 457 in six healthy humans. Radiation absorbed doses were estimated by the MIRD scheme implemented in OLINDA/EXM 1.1 software. RESULTS: Organs with the longest residence time were the liver, lungs, and brain. The organs with the highest radiation doses were the kidneys, liver, and pancreas. The effective dose delivered by [(11)C]FLB 457 is 5.9 μSv/MBq, similar to those of other (11)C-labeled tracers. CONCLUSIONS: This effective dose would allow multiple scans in the same individual based on prevailing maximum recommended-dose guidelines in the USA and Europe.
Authors: Kavya Prasad; Erik F J de Vries; Philip H Elsinga; Rudi A J O Dierckx; Aren van Waarde Journal: Int J Mol Sci Date: 2021-02-09 Impact factor: 5.923
Authors: Lucas Rischka; Matej Murgaš; Verena Pichler; Chrysoula Vraka; Ivo Rausch; Dietmar Winkler; Lukas Nics; Sazan Rasul; Leo Robert Silberbauer; Murray Bruce Reed; Godber Mathis Godbersen; Jakob Unterholzner; Patricia Handschuh; Gregor Gryglewski; Thomas Mindt; Markus Mitterhauser; Andreas Hahn; Simon Mensah Ametamey; Wolfgang Wadsak; Rupert Lanzenberger; Marcus Hacker Journal: EJNMMI Res Date: 2022-08-26 Impact factor: 3.434