| Literature DB >> 24074842 |
Hardesh K Maurya1, Ruby Verma, Saba Alam, Shweta Pandey, Vinay Pathak, Sandeep Sharma, Kishore K Srivastava, Arvind S Negi, Atul Gupta.
Abstract
Various substituted 5,6-dihydro-8-methoxybenzo[h]quinazolin-2-amine, 1-(3-(4-alkoxyphenyl)-7-methoxy-3,3a,4,5-tetrahydro-2H benzo[g]indazol-2-yl)ethanone, pyrazole and 2,6-diarylpyridine derivatives have been synthesized in good yields by an efficient methodology. The synthesized compounds (4-23) were evaluated for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv strain. Compounds 6a, 6c, 8a, 19a and 19e exhibited significant anti-tubercular activity at MIC values 50, 100, 50, 25 and 100μM concentration. In vitro cytotoxicity data using THP-1 cells indicated that most active compound 19a is safe as its MIC value is much lower than the cytotoxic value.Entities:
Keywords: AFRWBGJRWRHQOV-UHFFFAOYSA-N; AJTJGWQHYALTSC-UHFFFAOYSA-N; AKKATVMDHBEASX-UHFFFAOYSA-N; AYZGFAJCOVMXLA-UHFFFAOYSA-N; Antitubercular; CFOCPVQZZLPMIO-UHFFFAOYSA-N; CMWJZWOGUWCFQV-UHFFFAOYSA-N; CTEHHBOBZOCAIT-UHFFFAOYSA-N; CTODEFQZHRGULH-UHFFFAOYSA-N; DBXRLXVTWNUHCR-UHFFFAOYSA-N; DSCMLTAZYFVUPH-UHFFFAOYSA-N; DSLIJABHAVBSDV-UHFFFAOYSA-N; DWRUNZAIXLCFIP-UHFFFAOYSA-N; DXBULVYHTICWKT-UHFFFAOYSA-N; DXPKJYJXQICXLT-UHFFFAOYSA-N; Diarylpyridine; FIGVJXMTQDHJMQ-UHFFFAOYSA-N; GYXWNSDLDXGMGU-UHFFFAOYSA-N; HJBWBXRSRQEPRF-UHFFFAOYSA-N; ICSNLGPSRYBMBD-UHFFFAOYSA-N; IEVUNGKXTAPNJR-UHFFFAOYSA-N; ITENFASQOQYRFM-UHFFFAOYSA-N; Indazole; JADFRCNEVYMOAL-UHFFFAOYSA-N; KGHNKNWLMDRAQN-UHFFFAOYSA-N; KXDAEFPNCMNJSK-UHFFFAOYSA-N; LFUDVFOVNMIIIB-UHFFFAOYSA-N; LONGYNYRAPHNDS-UHFFFAOYSA-N; LOQHWUSEIHJYSE-UHFFFAOYSA-N; MHOUKRXEYUPHQG-UHFFFAOYSA-N; MKOXPFXGJVHBRH-UHFFFAOYSA-N; MMVNARZZQWUGQI-UHFFFAOYSA-N; MZCGMLMIRVVUSZ-UHFFFAOYSA-N; MZWNQLWLROXGST-UHFFFAOYSA-N; NFJFJJLADCFCHO-UHFFFAOYSA-N; NKPNESPVSMHQPA-ZRDIBKRKSA-N; NQRYJNQNLNOLGT-UHFFFAOYSA-N; NXWRCPFWNLSYMG-UHFFFAOYSA-N; PAEYRUAPLGXYIJ-UHFFFAOYSA-N; PLGIFHJDPLCSPL-UHFFFAOYSA-N; POMGSLQHWNDZAP-UHFFFAOYSA-N; Pyrazole; QLIZWGWIQMJGMB-UHFFFAOYSA-N; QXQPWPCSFNZDEU-JLHYYAGUSA-N; Quinazoline; RLGJGDBTBWUXKU-UHFFFAOYSA-N; RMGFLMXDCGQKPS-UHFFFAOYSA-N; STGYTXNBWMZKBA-UHFFFAOYSA-N; UBABLIWJMXJJNH-UHFFFAOYSA-N; UPFBAUZYKBLCEO-ZRDIBKRKSA-N; VGLWVBWXBZWXJE-WUKNDPDISA-N; VMNKGGRIISDZAU-UHFFFAOYSA-N; VOISDZHTKJQPAM-UHFFFAOYSA-N; WDWWEAMPRRKLGH-UHFFFAOYSA-N; WGCBFZZUJQDDSF-UHFFFAOYSA-N; WJNQRYCMQPMUDS-PKNBQFBNSA-N; WNRWEBKEQARBKV-UHFFFAOYSA-N; WQMAANNAZKNUDL-UHFFFAOYSA-N; XBPOBCXHALHJFP-UHFFFAOYSA-N; XPAKBGQUORPCMO-PKNBQFBNSA-N; XRWQAJSVMIKRKF-UHFFFAOYSA-N; YNAVUWVOSKDBBP-UHFFFAOYSA-N; YWQRMQADBLJRKZ-UHFFFAOYSA-N; ZVGCJBIDARLIMB-UHFFFAOYSA-N; ZWKKHRLWUFOSPA-UHFFFAOYSA-N; ZXANSLBVWCBHPP-UHFFFAOYSA-N
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Year: 2013 PMID： 24074842 DOI： 10.1016/j.bmcl.2013.08.101
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823