Francesco Bertolini1. 1. Laboratory of Hematology-Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. Electronic address: Francesco.bertolini@ieo.it.
Abstract
INTRODUCTION/AIMS: Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased incidence, morbidity and mortality from several types of neoplastic diseases including postmenopausal breast cancer. METHODS AND RESULTS: Several investigators have recently studied the role of human white adipose tissue (WAT) progenitors in preclinical models of breast cancer. WAT progenitors were found to promote breast cancer local growth, angiogenesis, EMT, migration and metastatic spreading. Breast cancer patients with intraepithelial neoplasia who received autologous WAT cells for breast reconstruction after surgical removal of breast cancer showed an increased risk of recurrence of local events when compared to controls. DISCUSSION/ CONCLUSION: There is an urgent need for a better understanding of the role of WAT progenitors in breast cancer local and metastatic growth. A rigorous cancer screening and follow-up of patients enrolled for WAT progenitor-based therapies should be implemented.
INTRODUCTION/AIMS: Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased incidence, morbidity and mortality from several types of neoplastic diseases including postmenopausal breast cancer. METHODS AND RESULTS: Several investigators have recently studied the role of human white adipose tissue (WAT) progenitors in preclinical models of breast cancer. WAT progenitors were found to promote breast cancer local growth, angiogenesis, EMT, migration and metastatic spreading. Breast cancerpatients with intraepithelial neoplasia who received autologous WAT cells for breast reconstruction after surgical removal of breast cancer showed an increased risk of recurrence of local events when compared to controls. DISCUSSION/ CONCLUSION: There is an urgent need for a better understanding of the role of WAT progenitors in breast cancer local and metastatic growth. A rigorous cancer screening and follow-up of patients enrolled for WAT progenitor-based therapies should be implemented.
Authors: Manjusha Annaji; Ishwor Poudel; Sai H S Boddu; Robert D Arnold; Amit K Tiwari; R Jayachandra Babu Journal: Cancer Rep (Hoboken) Date: 2021-03-02
Authors: A Goldhirsch; E P Winer; A S Coates; R D Gelber; M Piccart-Gebhart; B Thürlimann; H-J Senn Journal: Ann Oncol Date: 2013-08-04 Impact factor: 32.976
Authors: Helian Feng; Alexander Gusev; Bogdan Pasaniuc; Lang Wu; Jirong Long; Zomoroda Abu-Full; Kristiina Aittomäki; Irene L Andrulis; Hoda Anton-Culver; Antonis C Antoniou; Adalgeir Arason; Volker Arndt; Kristan J Aronson; Banu K Arun; Ella Asseryanis; Paul L Auer; Jacopo Azzollini; Judith Balmaña; Rosa B Barkardottir; Daniel R Barnes; Daniel Barrowdale; Matthias W Beckmann; Sabine Behrens; Javier Benitez; Marina Bermisheva; Katarzyna Białkowska; Ana Blanco; Carl Blomqvist; Bram Boeckx; Natalia V Bogdanova; Stig E Bojesen; Manjeet K Bolla; Bernardo Bonanni; Ake Borg; Hiltrud Brauch; Hermann Brenner; Ignacio Briceno; Annegien Broeks; Thomas Brüning; Barbara Burwinkel; Qiuyin Cai; Trinidad Caldés; Maria A Caligo; Ian Campbell; Sander Canisius; Daniele Campa; Brian D Carter; Jonathan Carter; Jose E Castelao; Jenny Chang-Claude; Stephen J Chanock; Hans Christiansen; Wendy K Chung; Kathleen B M Claes; Christine L Clarke; Fergus J Couch; Angela Cox; Simon S Cross; Cezary Cybulski; Kamila Czene; Mary B Daly; Miguel de la Hoya; Kim De Leeneer; Joe Dennis; Peter Devilee; Orland Diez; Susan M Domchek; Thilo Dörk; Isabel Dos-Santos-Silva; Alison M Dunning; Miriam Dwek; Diana M Eccles; Bent Ejlertsen; Carolina Ellberg; Christoph Engel; Mikael Eriksson; Peter A Fasching; Olivia Fletcher; Henrik Flyger; Florentia Fostira; Eitan Friedman; Lin Fritschi; Debra Frost; Marike Gabrielson; Patricia A Ganz; Susan M Gapstur; Judy Garber; Montserrat García-Closas; José A García-Sáenz; Mia M Gaudet; Graham G Giles; Gord Glendon; Andrew K Godwin; Mark S Goldberg; David E Goldgar; Anna González-Neira; Mark H Greene; Jacek Gronwald; Pascal Guénel; Christopher A Haiman; Per Hall; Ute Hamann; Christopher Hake; Wei He; Jane Heyworth; Frans B L Hogervorst; Antoinette Hollestelle; Maartje J Hooning; Robert N Hoover; John L Hopper; Guanmengqian Huang; Peter J Hulick; Keith Humphreys; Evgeny N Imyanitov; Claudine Isaacs; Milena Jakimovska; Anna Jakubowska; Paul James; Ramunas Janavicius; Rachel C Jankowitz; Esther M John; Nichola Johnson; Vijai Joseph; Audrey Jung; Beth Y Karlan; Elza Khusnutdinova; Johanna I Kiiski; Irene Konstantopoulou; Vessela N Kristensen; Yael Laitman; Diether Lambrechts; Conxi Lazaro; Dominique Leroux; Goska Leslie; Jenny Lester; Fabienne Lesueur; Noralane Lindor; Sara Lindström; Wing-Yee Lo; Jennifer T Loud; Jan Lubiński; Enes Makalic; Arto Mannermaa; Mehdi Manoochehri; Siranoush Manoukian; Sara Margolin; John W M Martens; Maria E Martinez; Laura Matricardi; Tabea Maurer; Dimitrios Mavroudis; Lesley McGuffog; Alfons Meindl; Usha Menon; Kyriaki Michailidou; Pooja M Kapoor; Austin Miller; Marco Montagna; Fernando Moreno; Lidia Moserle; Anna M Mulligan; Taru A Muranen; Katherine L Nathanson; Susan L Neuhausen; Heli Nevanlinna; Ines Nevelsteen; Finn C Nielsen; Liene Nikitina-Zake; Kenneth Offit; Edith Olah; Olufunmilayo I Olopade; Håkan Olsson; Ana Osorio; Janos Papp; Tjoung-Won Park-Simon; Michael T Parsons; Inge S Pedersen; Ana Peixoto; Paolo Peterlongo; Julian Peto; Paul D P Pharoah; Kelly-Anne Phillips; Dijana Plaseska-Karanfilska; Bruce Poppe; Nisha Pradhan; Karolina Prajzendanc; Nadege Presneau; Kevin Punie; Katri Pylkäs; Paolo Radice; Johanna Rantala; Muhammad Usman Rashid; Gad Rennert; Harvey A Risch; Mark Robson; Atocha Romero; Emmanouil Saloustros; Dale P Sandler; Catarina Santos; Elinor J Sawyer; Marjanka K Schmidt; Daniel F Schmidt; Rita K Schmutzler; Minouk J Schoemaker; Rodney J Scott; Priyanka Sharma; Xiao-Ou Shu; Jacques Simard; Christian F Singer; Anne-Bine Skytte; Penny Soucy; Melissa C Southey; John J Spinelli; Amanda B Spurdle; Jennifer Stone; Anthony J Swerdlow; William J Tapper; Jack A Taylor; Manuel R Teixeira; Mary Beth Terry; Alex Teulé; Mads Thomassen; Kathrin Thöne; Darcy L Thull; Marc Tischkowitz; Amanda E Toland; Rob A E M Tollenaar; Diana Torres; Thérèse Truong; Nadine Tung; Celine M Vachon; Christi J van Asperen; Ans M W van den Ouweland; Elizabeth J van Rensburg; Ana Vega; Alessandra Viel; Paula Vieiro-Balo; Qin Wang; Barbara Wappenschmidt; Clarice R Weinberg; Jeffrey N Weitzel; Camilla Wendt; Robert Winqvist; Xiaohong R Yang; Drakoulis Yannoukakos; Argyrios Ziogas; Roger L Milne; Douglas F Easton; Georgia Chenevix-Trench; Wei Zheng; Peter Kraft; Xia Jiang Journal: Genet Epidemiol Date: 2020-03-01 Impact factor: 2.344