| Literature DB >> 24074570 |
Jiansen Du1, Hailing Xue, Jing Ma, Fang Liu, Jianhua Zhou, Yiming Shao, Wentao Qiao, Xinqi Liu.
Abstract
HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 gp41 evolved more basic and hydrophilic residues on its helix bundle surface. Based on sequence alignment, a hyper-mutant cluster located in the middle of HR2 heptads repeat was identified. The mutational study of these residues revealed that this site is important in HIV mediated cell-cell fusion and plays critical roles in conformational changes during viral invasion.Keywords: Crystal structure; HIV; Heptad repeat; Membrane fusion; gp41
Mesh：
Substances：
Year: 2013 PMID： 24074570 DOI： 10.1016/j.virol.2013.07.024
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616