Literature DB >> 24073373

Pancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.

Thomas A Mace1, Mark Bloomston, Gregory B Lesinski.   

Abstract

Pancreatic cancer-associated stellate cells secrete soluble factors, such as interleukin-6 (IL-6), that promote the accumulation of myeloid-derived suppressor cells via a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism. Targeting components of the IL-6/JAK/STAT3 signaling axis within the tumor stroma could therefore inhibit local immunosuppression and improve the efficacy of immunotherapeutic regimens against pancreatic cancer.

Entities:  

Keywords:  IL-6; STAT3; immunosuppression; myeloid-derived suppressor cells; pancreatic cancer stellate cells

Year:  2013        PMID： 24073373      PMCID： PMC3782129          DOI： 10.4161/onci.24891

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

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Authors:  Rachel F Gabitass; Nicola E Annels; Deborah D Stocken; Hardev A Pandha; Gary W Middleton
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Journal:  Cancer Cell       Date:  2012-06-12       Impact factor: 31.743

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7.  The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics.

Authors:  R Kang; D Tang; N E Schapiro; T Loux; K M Livesey; T R Billiar; H Wang; B Van Houten; M T Lotze; H J Zeh
Journal:  Oncogene       Date:  2013-01-14       Impact factor: 9.867

Review 8.  Advances in targeting cell surface signalling molecules for immune modulation.

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10.  Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.

Authors:  Thomas A Mace; Zeenath Ameen; Amy Collins; Sylwia Wojcik; Markus Mair; Gregory S Young; James R Fuchs; Tim D Eubank; Wendy L Frankel; Tanios Bekaii-Saab; Mark Bloomston; Gregory B Lesinski
Journal:  Cancer Res       Date:  2013-03-20       Impact factor: 12.701
  10 in total
  24 in total

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Authors:  Jessica L Rastad; William R Green
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Review 3.  Pancreatic cancer stroma: understanding biology leads to new therapeutic strategies.

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Review 5.  Kras and Tumor Immunity: Friend or Foe?

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6.  IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

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Review 7.  The evolution into personalized therapies in pancreatic ductal adenocarcinoma: challenges and opportunities.

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Review 9.  STAT3 in the systemic inflammation of cancer cachexia.

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10.  Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.

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