Literature DB >> 2407313

Immunoelectron microscopic localization of amyloid beta protein in the diffuse plaques of Alzheimer-type dementia.

H Yamaguchi1, Y Nakazato, S Hirai, M Shoji.   

Abstract

We examined the ultrastructural localization of beta protein in diffuse plaques of Alzheimer brain by indirect immunoperoxidase technique. Intense immunoreaction products, scattered sporadically in the diffuse plaques, were located on small bundles of several amyloid fibrils and/or amorphous materials between amyloid-related cell processes (ARCP). Deposits of beta protein were also seen on parts of the cell membrane of ARCP, suggesting the importance of ARCP in plaque amyloid deposits.

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Year:  1990        PMID: 2407313     DOI: 10.1016/0006-8993(90)90416-9

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  20 in total

1.  Deposition of beta/A4 protein along neuronal plasma membranes in diffuse senile plaques.

Authors:  A Probst; D Langui; S Ipsen; N Robakis; J Ulrich
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

2.  Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.

Authors:  H Yamaguchi; Y Nakazato; M Shoji; K Okamoto; Y Ihara; M Morimatsu; S Hirai
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

Review 3.  Neuropathological correlates of amyloid PET imaging in Down syndrome.

Authors:  Eric E Abrahamson; Elizabeth Head; Ira T Lott; Benjamin L Handen; Elliott J Mufson; Bradley T Christian; William E Klunk; Milos D Ikonomovic
Journal:  Dev Neurobiol       Date:  2019-08-17       Impact factor: 3.964

4.  Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

Authors:  C A Davies; D M Mann
Journal:  Am J Pathol       Date:  1993-12       Impact factor: 4.307

5.  Light scattering analysis of fibril growth from the amino-terminal fragment beta(1-28) of beta-amyloid peptide.

Authors:  C L Shen; G L Scott; F Merchant; R M Murphy
Journal:  Biophys J       Date:  1993-12       Impact factor: 4.033

6.  Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain.

Authors:  A D Snow; R T Sekiguchi; D Nochlin; R N Kalaria; K Kimata
Journal:  Am J Pathol       Date:  1994-02       Impact factor: 4.307

7.  Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.

Authors:  L J Martin; C A Pardo; L C Cork; D L Price
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

8.  Effects of injected Alzheimer beta-amyloid cores in rat brain.

Authors:  S A Frautschy; A Baird; G M Cole
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

9.  Ultrastructure of diffuse plaques in senile dementia of the Alzheimer type: comparison with primitive plaques.

Authors:  H Yamaguchi; Y Nakazato; M Shoji; M Takatama; S Hirai
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

10.  Morphology of cerebral plaque-like lesions in hereditary cerebral hemorrhage with amyloidosis (Dutch).

Authors:  M L Maat-Schieman; S G van Duinen; J Haan; R A Roos
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

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