Literature DB >> 24071972

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution.

Lei Hu1, Fredrik Schaufelberger, Yan Zhang, Olof Ramström.   

Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

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Year:  2013        PMID： 24071972     DOI： 10.1039/c3cc45551c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Dynamic Covalent Kinetic Resolution.

Authors:  Yan Zhang; Yang Zhang; Olof Ramström
Journal:  Catal Rev Sci Eng       Date:  2019-09-11       Impact factor: 20.217

2.  Enzyme classification using complex dynamic hemithioacetal systems.

Authors:  Yan Zhang; H Surangi N Jayawardena; Mingdi Yan; Olof Ramström
Journal:  Chem Commun (Camb)       Date:  2016-03-18       Impact factor: 6.222

3.  Efficient asymmetric synthesis of 1-cyano-tetrahydroisoquinolines from lipase dual activity and opposite enantioselectivities in α-Aminonitrile resolution.

Authors:  Morakot Sakulsombat; Pornrapee Vongvilai; Olof Ramström
Journal:  Chemistry       Date:  2014-07-23       Impact factor: 5.236

4.  Dynamic Covalent Chemistry of Aldehyde Enamines: BiIII - and ScIII -Catalysis of Amine-Enamine Exchange.

Authors:  Yang Zhang; Sheng Xie; Mingdi Yan; Olof Ramström
Journal:  Chemistry       Date:  2017-08-09       Impact factor: 5.236
  4 in total

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