RATIONALE: The effect of endotoxin on asthma morbidity in urban populations is unclear. OBJECTIVES: To determine if indoor pollutant exposure modifies the relationships between indoor airborne endotoxin and asthma health and morbidity. METHODS: One hundred forty-six children and adolescents with persistent asthma underwent repeated clinical assessments at 0, 3, 6, 9, and 12 months. Home visits were conducted at the same time points for assessment of airborne nicotine, endotoxin, and nitrogen dioxide (NO2) concentrations. The effect of concomitant pollutant exposure on relationships between endotoxin and asthma outcomes were examined in stratified analyses and statistical models with interaction terms. MEASUREMENTS AND MAIN RESULTS: Both air nicotine and NO2 concentrations modified the relationships between airborne endotoxin and asthma outcomes. Among children living in homes with no detectable air nicotine, higher endotoxin was inversely associated with acute visits and oral corticosteroid bursts, whereas among those in homes with detectable air nicotine, endotoxin was positively associated with these outcomes (interaction P value = 0.004 and 0.07, respectively). Among children living in homes with lower NO2 concentrations (<20 ppb), higher endotoxin was positively associated with acute visits, whereas among those living in homes with higher NO2 concentrations, endotoxin was negatively associated with acute visit (interaction P value = 0.05). NO2 also modified the effect of endotoxin on asthma symptom outcomes in a similar manner. CONCLUSIONS: The effects of household airborne endotoxin exposure on asthma are modified by coexposure to air nicotine and NO2, and these pollutants have opposite effects on the relationships between endotoxin and asthma-related outcomes.
RATIONALE: The effect of endotoxin on asthma morbidity in urban populations is unclear. OBJECTIVES: To determine if indoor pollutant exposure modifies the relationships between indoor airborne endotoxin and asthma health and morbidity. METHODS: One hundred forty-six children and adolescents with persistent asthma underwent repeated clinical assessments at 0, 3, 6, 9, and 12 months. Home visits were conducted at the same time points for assessment of airborne nicotine, endotoxin, and nitrogen dioxide (NO2) concentrations. The effect of concomitant pollutant exposure on relationships between endotoxin and asthma outcomes were examined in stratified analyses and statistical models with interaction terms. MEASUREMENTS AND MAIN RESULTS: Both air nicotine and NO2 concentrations modified the relationships between airborne endotoxin and asthma outcomes. Among children living in homes with no detectable air nicotine, higher endotoxin was inversely associated with acute visits and oral corticosteroid bursts, whereas among those in homes with detectable air nicotine, endotoxin was positively associated with these outcomes (interaction P value = 0.004 and 0.07, respectively). Among children living in homes with lower NO2 concentrations (<20 ppb), higher endotoxin was positively associated with acute visits, whereas among those living in homes with higher NO2 concentrations, endotoxin was negatively associated with acute visit (interaction P value = 0.05). NO2 also modified the effect of endotoxin on asthma symptom outcomes in a similar manner. CONCLUSIONS: The effects of household airborne endotoxin exposure on asthma are modified by coexposure to air nicotine and NO2, and these pollutants have opposite effects on the relationships between endotoxin and asthma-related outcomes.
Authors: Stephen J Reynolds; Peter S Thorne; Kelley J Donham; Elizabeth A Croteau; Kevin M Kelly; Daniel Lewis; Mike Whitmer; D J J Heederik; Jeroen Douwes; Ian Connaughton; Sharon Koch; Per Malmberg; Britt-Marie Larsson; Donald K Milton Journal: AIHA J (Fairfax, Va) Date: 2002 Jul-Aug
Authors: Ulrike Gehring; Wolfgang Bischof; Bärbel Fahlbusch; Heinz-Erich Wichmann; Joachim Heinrich Journal: Am J Respir Crit Care Med Date: 2002-10-01 Impact factor: 21.405
Authors: Stephen J Reynolds; Donald K Milton; Dick Heederik; Peter S Thorne; Kelley J Donham; Elizabeth A Croteau; Kevin M Kelly; Jeroen Douwes; Daniel Lewis; Mike Whitmer; Ian Connaughton; Sharon Koch; Per Malmberg; Britt-Marie Larsson; Jim Deddens; Anita Saraf; Lennart Larsson Journal: J Environ Monit Date: 2005-10-11
Authors: Karin A Pacheco; Charles McCammon; Andrew H Liu; Peter S Thorne; Marsha E O'Neill; John Martyny; Lee S Newman; Richard F Hamman; Cecile S Rose Journal: Am J Respir Crit Care Med Date: 2003-04-01 Impact factor: 21.405
Authors: Charlotte Braun-Fahrländer; Josef Riedler; Udo Herz; Waltraud Eder; Marco Waser; Leticia Grize; Soyoun Maisch; David Carr; Florian Gerlach; Albrecht Bufe; Roger P Lauener; Rudolf Schierl; Harald Renz; Dennis Nowak; Erika von Mutius Journal: N Engl J Med Date: 2002-09-19 Impact factor: 91.245
Authors: Wanda Phipatanakul; Juan C Celedón; Benjamin A Raby; Augusto A Litonjua; Donald K Milton; Diane Sredl; Scott T Weiss; Diane R Gold Journal: Pediatrics Date: 2004-07 Impact factor: 7.124
Authors: Christina M Pacheco; Christina E Ciaccio; Niaman Nazir; Christine M Daley; Anita DiDonna; Won S Choi; Charles S Barnes; Lanny J Rosenwasser Journal: Allergy Asthma Proc Date: 2014 Nov-Dec Impact factor: 2.587
Authors: Nirupama Putcha; R Graham Barr; Meilan K Han; Prescott G Woodruff; Eugene R Bleecker; Richard E Kanner; Fernando J Martinez; Benjamin M Smith; Donald P Tashkin; Russell P Bowler; Mark D Eisner; Stephen I Rennard; Robert A Wise; Nadia N Hansel Journal: Thorax Date: 2016-03-09 Impact factor: 9.139
Authors: Kamau O Peters; D' Ann L Williams; Salahadin Abubaker; Jean Curtin-Brosnan; Meredith C McCormack; Roger Peng; Patrick N Breysse; Elizabeth C Matsui; Nadia N Hansel; Gregory B Diette; Paul T Strickland Journal: J Expo Sci Environ Epidemiol Date: 2016-12-14 Impact factor: 5.563