Literature DB >> 2406643

Intraventricular injection of an N-methyl-D-aspartate antagonist disrupts vestibular compensation.

A J Sansom1, C L Darlington, P F Smith.   

Abstract

Guinea pigs which had compensated for a unilateral labyrinthectomy exhibited a loss of ocular motor and postural compensation when a 40 or 20 mM concentration of the NMDA antagonist CPP, was injected through a cannula implanted in the IVth ventricle close to the vestibular nuclei. Similar injections of artificial cerebrospinal fluid did not induce loss of compensation. These results suggest that NMDA receptors may contribute to vestibular compensation in the guinea pig.

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Year:  1990        PMID： 2406643     DOI： 10.1016/0028-3908(90)90087-8

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  4 in total

Review 1.  Excitatory amino acid receptors in normal and abnormal vestibular function.

Authors:  P F Smith; C de Waele; P P Vidal; C L Darlington
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

2.  Low-frequency stimulation cancels the high-frequency-induced long-lasting effects in the rat medial vestibular nuclei.

Authors:  S Grassi; V E Pettorossi; M Zampolini
Journal:  J Neurosci       Date:  1996-05-15       Impact factor: 6.167

Review 3.  Molecular mechanisms of brainstem plasticity. The vestibular compensation model.

Authors:  C L Darlington; H Flohr; P F Smith
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

4.  Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs.

Authors:  A J Sansom; C L Darlington; P F Smith; D P Gilchrist; C J Keenan; R Kenyon
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972
  4 in total

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