Literature DB >> 24064490

Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field (17)O MR spectroscopy.

Weina Cui1, Xiao-Hong Zhu, Manda L Vollmers, Emily T Colonna, Gregor Adriany, Brandon Tramm, Janet M Dubinsky, Gülin Öz.   

Abstract

To assess cerebral energetics in transgenic mouse models of neurologic disease, a robust, efficient, and practical method for quantification of cerebral oxygen consumption is needed. (17)O magnetic resonance spectroscopy (MRS) has been validated to measure cerebral metabolic rate of oxygen (CMRO2) in the rat brain; however, mice present unique challenges because of their small size. We show that CMRO2 measurements with (17)O MRS in the mouse brain are highly reproducible using 16.4 Tesla and a newly designed oxygen delivery system. The method can be utilized to measure mitochondrial function in mice quickly and repeatedly, without oral intubation, and has numerous potential applications to study cerebral energetics.

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Year:  2013        PMID： 24064490      PMCID： PMC3851910          DOI： 10.1038/jcbfm.2013.172

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  15 in total

1.  In vitro and in vivo studies of 17O NMR sensitivity at 9.4 and 16.4 T.

Authors:  Ming Lu; Yi Zhang; Kamil Ugurbil; Wei Chen; Xiao-Hong Zhu
Journal:  Magn Reson Med       Date:  2012-07-06       Impact factor: 4.668

2.  Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.

Authors:  O A Andreassen; A Dedeoglu; R J Ferrante; B G Jenkins; K L Ferrante; M Thomas; A Friedlich; S E Browne; G Schilling; D R Borchelt; S M Hersch; C A Ross; M F Beal
Journal:  Neurobiol Dis       Date:  2001-06       Impact factor: 5.996

3.  A novel method for endotracheal intubation of mice and rats used in imaging studies.

Authors:  Belinda Rivera; Shonna Miller; Ellana Brown; Roger Price
Journal:  Contemp Top Lab Anim Sci       Date:  2005-03

Review 4.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.

Authors:  Michael T Lin; M Flint Beal
Journal:  Nature       Date:  2006-10-19       Impact factor: 49.962

Review 5.  In vivo 17O NMR approaches for brain study at high field.

Authors:  Xiao-Hong Zhu; Nanyin Zhang; Yi Zhang; Xiaoliang Zhang; Kamil Ugurbil; Wei Chen
Journal:  NMR Biomed       Date:  2005-04       Impact factor: 4.044

6.  Noninvasive and three-dimensional imaging of CMRO(2) in rats at 9.4 T: reproducibility test and normothermia/hypothermia comparison study.

Authors:  Xiao-Hong Zhu; Yi Zhang; Nanyin Zhang; Kamil Ugurbil; Wei Chen
Journal:  J Cereb Blood Flow Metab       Date:  2006-11-29       Impact factor: 6.200

7.  Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography.

Authors:  M A Mintun; M E Raichle; W R Martin; P Herscovitch
Journal:  J Nucl Med       Date:  1984-02       Impact factor: 10.057

8.  Tightly coupled brain activity and cerebral ATP metabolic rate.

Authors:  Fei Du; Xiao-Hong Zhu; Yi Zhang; Michael Friedman; Nanyin Zhang; Kâmil Ugurbil; Wei Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-28       Impact factor: 11.205

9.  Simplified methods for calculating cerebral metabolic rate of oxygen based on 17O magnetic resonance spectroscopic imaging measurement during a short 17O2 inhalation.

Authors:  Nanyin Zhang; Xiao-Hong Zhu; Hao Lei; Kamil Ugurbil; Wei Chen
Journal:  J Cereb Blood Flow Metab       Date:  2004-08       Impact factor: 6.200

10.  Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.

Authors:  Kei Watase; Jennifer R Gatchel; Yaling Sun; Effat Emamian; Richard Atkinson; Ronald Richman; Hidehiro Mizusawa; Harry T Orr; Chad Shaw; Huda Y Zoghbi
Journal:  PLoS Med       Date:  2007-05       Impact factor: 11.069
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  18 in total

Review 1.  Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review.

Authors:  Yuchi Liu; Yuning Gu; Xin Yu
Journal:  Quant Imaging Med Surg       Date:  2017-12

2.  The mass transfer coefficient for oxygen transport from blood to tissue in cerebral cortex.

Authors:  Timothy W Secomb; Katherine V Bullock; David A Boas; Sava Sakadžić
Journal:  J Cereb Blood Flow Metab       Date:  2019-08-18       Impact factor: 6.200

3.  Two-photon microscopy measurement of cerebral metabolic rate of oxygen using periarteriolar oxygen concentration gradients.

Authors:  Sava Sakadžić; Mohammad A Yaseen; Rajeshwer Jaswal; Emmanuel Roussakis; Anders M Dale; Richard B Buxton; Sergei A Vinogradov; David A Boas; Anna Devor
Journal:  Neurophotonics       Date:  2016-10-17       Impact factor: 3.593

4.  The capillary bed offers the largest hemodynamic resistance to the cortical blood supply.

Authors:  Ian Gopal Gould; Philbert Tsai; David Kleinfeld; Andreas Linninger
Journal:  J Cereb Blood Flow Metab       Date:  2016-10-10       Impact factor: 6.200

5.  The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice.

Authors:  Eugenio Gutiérrez-Jiménez; Hugo Angleys; Peter Mondrup Rasmussen; Irene Klærke Mikkelsen; Kim Mouridsen; Leif Østergaard
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-09       Impact factor: 6.200

Review 6.  Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics.

Authors:  Vilakshan Alambyan; Jonathan Pace; Persen Sukpornchairak; Xin Yu; Hamza Alnimir; Ryan Tatton; Gautham Chitturu; Anisha Yarlagadda; Ciro Ramos-Estebanez
Journal:  Neurotherapeutics       Date:  2020-04       Impact factor: 7.620

7.  Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex.

Authors:  Jose T Celaya-Alcala; Grace V Lee; Amy F Smith; Bohan Li; Sava Sakadžić; David A Boas; Timothy W Secomb
Journal:  J Cereb Blood Flow Metab       Date:  2020-06-05       Impact factor: 6.200

8.  Spatial landscape of oxygen in and around microvasculature during epileptic events.

Authors:  Cong Zhang; Mohammad Moeini; Frédéric Lesage
Journal:  Neurophotonics       Date:  2017-03-11       Impact factor: 3.593

9.  Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress.

Authors:  Song Lou; Victoria C Lepak; Lynn E Eberly; Brian Roth; Weina Cui; Xiao-Hong Zhu; Gülin Öz; Janet M Dubinsky
Journal:  Hum Mol Genet       Date:  2016-05-18       Impact factor: 6.150

Review 10.  In vivo17O MRS imaging - Quantitative assessment of regional oxygen consumption and perfusion rates in living brain.

Authors:  Xiao-Hong Zhu; Wei Chen
Journal:  Anal Biochem       Date:  2016-08-26       Impact factor: 3.365
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