Jian Guo1, Ning Chen1, Rong Li2, Qizhu Wu3, Huafu Chen2, Qiyong Gong3, Li He4. 1. Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, PR China. 2. Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610041, PR China. 3. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, PR China. 4. Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, PR China. Electronic address: heli2003new@126.com.
Abstract
OBJECTIVE: To investigate regional activity abnormalities in the resting state in patients with transient ischaemic attack (TIA) using a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) and to examine the relationship between regional activity abnormalities and clinical variables. METHODS: Resting-state fMRI was conducted in 21 patients with right-sided TIA and in 21 healthy volunteers. The ReHo was calculated to assess the strength of the local signal synchrony and was compared between the two groups. RESULTS: Compared with the controls, the TIA patients exhibited a decreased ReHo in the right dorsolateral prefrontal cortex (dlPFC), the right inferior prefrontal cortex (iPFC), the right ventral anterior cingulate cortex (vACC) and the right dorsal posterior cingulate cortex (dPCC). In addition, the mean ReHo values in the right dlPFC and the right iPFC were significantly correlated with the Montreal Cognitive Assessment (MoCA) in TIA patients. CONCLUSIONS: Neural activities in the resting state are changed in TIA patients even without visible ischaemic lesions on conventional MRI. The positive correlation between the ReHo of resting-state fMRI and cognition suggests that ReHo could be a promising tool to observe the neurobiological consequences of TIA. SIGNIFICANCE: The present study revealed abnormal local synchronisation of spontaneous neural activities in patients with TIA.
OBJECTIVE: To investigate regional activity abnormalities in the resting state in patients with transient ischaemic attack (TIA) using a regional homogeneity (ReHo) method combined with functional magnetic resonance imaging (fMRI) and to examine the relationship between regional activity abnormalities and clinical variables. METHODS: Resting-state fMRI was conducted in 21 patients with right-sided TIA and in 21 healthy volunteers. The ReHo was calculated to assess the strength of the local signal synchrony and was compared between the two groups. RESULTS: Compared with the controls, the TIApatients exhibited a decreased ReHo in the right dorsolateral prefrontal cortex (dlPFC), the right inferior prefrontal cortex (iPFC), the right ventral anterior cingulate cortex (vACC) and the right dorsal posterior cingulate cortex (dPCC). In addition, the mean ReHo values in the right dlPFC and the right iPFC were significantly correlated with the Montreal Cognitive Assessment (MoCA) in TIApatients. CONCLUSIONS: Neural activities in the resting state are changed in TIApatients even without visible ischaemic lesions on conventional MRI. The positive correlation between the ReHo of resting-state fMRI and cognition suggests that ReHo could be a promising tool to observe the neurobiological consequences of TIA. SIGNIFICANCE: The present study revealed abnormal local synchronisation of spontaneous neural activities in patients with TIA.