| Literature DB >> 24063998 |
T Kamatani1, S Shiogama, Y Yoshihama, S Kondo, T Shirota, S Shintani.
Abstract
The objective of this study was to evaluate cytokines in unstimulated whole saliva (UWS) of oral squamous cell carcinoma (OSCC) patients as compared to those with pre- and post-operation for evaluation as markers of OSCC. Sixteen OSCC patients were included in this study. Cytokine concentrations in resting saliva were measured using a Bio-Plex suspension array system. Only interleukin-1 (IL-1) beta showed significantly different cytokine concentration in saliva between pre- and post-operation. IL-1 beta was released from cultured OSCC cells confirmed by ELISA and immunohistochemistry. From this study, IL-1 beta in UWS may be useful for detection of early stage OSCC. More studies are needed to accept the utility of IL-1 beta in UWS for predicting, diagnosis and evaluation of OSCC.Entities:
Keywords: Cytokines; Interleukin-1 beta; Oral squamous cell carcinoma; Unstimulated whole saliva
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Year: 2013 PMID： 24063998 DOI： 10.1016/j.cyto.2013.08.011
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861