BACKGROUND: Although cryoballoon based catheter ablation is an effective therapeutic option in atrial fibrillation (AF), a significant amount of patients failed to remain in sinus rhythm at long term follow-up. Appropriate selection of patients for catheter ablation reduces unnecessary interventions and prevents complications related with catheter ablation. The purpose of our study is to propose a new scoring system in the prediction of recurrence after AF ablation with cryoballoon. METHOD: A total of 236 patients (54% male, age 54.6 ± 10.45 years and 79.6% paroxysmal) with symptomatic AF underwent an index cryoablation. The first 3 months after AF ablation is defined as blanking period. Predictors of AF recurrence after cryoablation were analyzed with multivariate Cox regression analysis. BASE-AF2 score [acronym stands for Body mass index >28 kg/m(2) (1); Atrial dilatation >40 mm (1); current Smoking (1); Early recurrence (1); duration of AF history >6 years (1) and non-paroxysmal type (1) of AF] is identified by the total number of significant predictors of recurrence in each patient (range=0-6). RESULTS: At median 20 (range: 12-30) months follow-up, 74.5% of the patients were free from AF recurrence. Of these patients, 64 (27.1%) patients had a BASE-AF2 score of ≥3. Patients with AF recurrence had a higher mean BASE-AF2 score (3.27±0.82 vs. 1.1 ± 0.95, p<0.001) compared to patients without AF recurrence. ROC analysis showed that a BASE-AF2 score of ≥3 well predicted AF recurrence with a sensitivity of 80.8% and a specificity of 91.6% (AUC=0.94; 95% CI: 0.89-0.97, p<0.001). A BASE-AF2 score of ≥3 was found to be an independent predictor of AF recurrence (HR: 3.34, 95% CI: 2.34-4.76, p=0.001). CONCLUSION: BASE-AF2, which was identified as a new scoring system, has well predicted AF recurrence and could be helpful in selecting appropriate patients for interventional strategy.
BACKGROUND: Although cryoballoon based catheter ablation is an effective therapeutic option in atrial fibrillation (AF), a significant amount of patients failed to remain in sinus rhythm at long term follow-up. Appropriate selection of patients for catheter ablation reduces unnecessary interventions and prevents complications related with catheter ablation. The purpose of our study is to propose a new scoring system in the prediction of recurrence after AF ablation with cryoballoon. METHOD: A total of 236 patients (54% male, age 54.6 ± 10.45 years and 79.6% paroxysmal) with symptomatic AF underwent an index cryoablation. The first 3 months after AF ablation is defined as blanking period. Predictors of AF recurrence after cryoablation were analyzed with multivariate Cox regression analysis. BASE-AF2 score [acronym stands for Body mass index >28 kg/m(2) (1); Atrial dilatation >40 mm (1); current Smoking (1); Early recurrence (1); duration of AF history >6 years (1) and non-paroxysmal type (1) of AF] is identified by the total number of significant predictors of recurrence in each patient (range=0-6). RESULTS: At median 20 (range: 12-30) months follow-up, 74.5% of the patients were free from AF recurrence. Of these patients, 64 (27.1%) patients had a BASE-AF2 score of ≥3. Patients with AF recurrence had a higher mean BASE-AF2 score (3.27±0.82 vs. 1.1 ± 0.95, p<0.001) compared to patients without AF recurrence. ROC analysis showed that a BASE-AF2 score of ≥3 well predicted AF recurrence with a sensitivity of 80.8% and a specificity of 91.6% (AUC=0.94; 95% CI: 0.89-0.97, p<0.001). A BASE-AF2 score of ≥3 was found to be an independent predictor of AF recurrence (HR: 3.34, 95% CI: 2.34-4.76, p=0.001). CONCLUSION: BASE-AF2, which was identified as a new scoring system, has well predicted AF recurrence and could be helpful in selecting appropriate patients for interventional strategy.
Authors: Jelena Kornej; Gerhard Hindricks; M Benjamin Shoemaker; Daniela Husser; Arash Arya; Philipp Sommer; Sascha Rolf; Pablo Saavedra; Arvindh Kanagasundram; S Patrick Whalen; Jay Montgomery; Christopher R Ellis; Dawood Darbar; Andreas Bollmann Journal: Clin Res Cardiol Date: 2015-04-17 Impact factor: 5.460
Authors: Aakash A Bavishi; Rachel M Kaplan; Graham Peigh; Celso L Diaz; Jayson R Baman; Amar Trivedi; Jeremiah Wasserlauf; Mark J Shen; Prasongchai Sattayaprasert; Alexandru B Chicos; Susan Kim; Nishant Verma; Rishi Arora; Albert Lin; Bradley P Knight; Rod S Passman Journal: Pacing Clin Electrophysiol Date: 2019-04-09 Impact factor: 1.976
Authors: Jens Cosedis Nielsen; Yenn-Jiang Lin; Marcio Jansen de Oliveira Figueiredo; Alireza Sepehri Shamloo; Alberto Alfie; Serge Boveda; Nikolaos Dagres; Dario Di Toro; Lee L Eckhardt; Kenneth Ellenbogen; Carina Hardy; Takanori Ikeda; Aparna Jaswal; Elizabeth Kaufman; Andrew Krahn; Kengo Kusano; Valentina Kutyifa; Han S Lim; Gregory Y H Lip; Santiago Nava-Townsend; Hui-Nam Pak; Gerardo Rodríguez Diez; William Sauer; Anil Saxena; Jesper Hastrup Svendsen; Diego Vanegas; Marmar Vaseghi; Arthur Wilde; T Jared Bunch; Alfred E Buxton; Gonzalo Calvimontes; Tze-Fan Chao; Lars Eckardt; Heidi Estner; Anne M Gillis; Rodrigo Isa; Josef Kautzner; Philippe Maury; Joshua D Moss; Gi-Byung Nam; Brian Olshansky; Luis Fernando Pava Molano; Mauricio Pimentel; Mukund Prabhu; Wendy S Tzou; Philipp Sommer; Janice Swampillai; Alejandro Vidal; Thomas Deneke; Gerhard Hindricks; Christophe Leclercq Journal: Europace Date: 2020-08-01 Impact factor: 5.214
Authors: Marek Jastrzębski; Grzegorz Kiełbasa; Kamil Fijorek; Adam Bednarski; Aleksander Kusiak; Tomasz Sondej; Agnieszka Bednarek; Wiktoria Wojciechowska; Marek Rajzer Journal: J Arrhythm Date: 2021-05-20
Authors: Graham Peigh; Rachel M Kaplan; Aakash Bavishi; Celso L Diaz; Jayson R Baman; Richard Matiasz; Amar Trivedi; Prasongchai Sattayaprasert; Jeremiah Wasserlauf; Mark J Shen; Tatjana S Potpara; Alexandru B Chicos; Rishi Arora; Susan Kim; Albert Lin; Nishant Verma; Bradley P Knight; Rod S Passman Journal: J Interv Card Electrophysiol Date: 2019-07-20 Impact factor: 1.900