Literature DB >> 24063054

Rapamycin, anti-aging, and avoiding the fate of Tithonus.

Arlan Richardson1.   

Abstract

The discovery that rapamycin increased the lifespan of mice was recognized by Science as one of the top 10 scientific breakthroughs of 2009. In addition to increasing lifespan, Neff and colleagues show that while rapamycin improves several functions/pathologies that change with age, it has little effect on the majority of the physiological and structural parameters they evaluated. What do these data tell us about the ability of rapamycin to delay aging and improve quality of life, i.e., prevent the fate of Tithonus?

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Year:  2013        PMID： 24063054      PMCID： PMC3726178          DOI： 10.1172/jci70800

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  22 in total

1.  Rapamycin extends maximal lifespan in cancer-prone mice.

Authors:  Vladimir N Anisimov; Mark A Zabezhinski; Irina G Popovich; Tatiana S Piskunova; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Marina P Antoch; Mikhail V Blagosklonny
Journal:  Am J Pathol       Date:  2010-04-02       Impact factor: 4.307

2.  Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.

Authors:  J Halloran; S A Hussong; R Burbank; N Podlutskaya; K E Fischer; L B Sloane; S N Austad; R Strong; A Richardson; M J Hart; V Galvan
Journal:  Neuroscience       Date:  2012-06-28       Impact factor: 3.590

3.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Authors:  Brinda Ravikumar; Coralie Vacher; Zdenek Berger; Janet E Davies; Shouqing Luo; Lourdes G Oroz; Francesco Scaravilli; Douglas F Easton; Rainer Duden; Cahir J O'Kane; David C Rubinsztein
Journal:  Nat Genet       Date:  2004-05-16       Impact factor: 38.330

4.  Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice.

Authors:  Teruaki Fujishita; Koji Aoki; Heidi A Lane; Masahiro Aoki; Makoto M Taketo
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-03       Impact factor: 11.205

5.  Rapamycin extends life and health in C57BL/6 mice.

Authors:  Yiqiang Zhang; Alex Bokov; John Gelfond; Vanessa Soto; Yuji Ikeno; Gene Hubbard; Vivian Diaz; Lauren Sloane; Keith Maslin; Stephen Treaster; Samantha Réndon; Holly van Remmen; Walter Ward; Martin Javors; Arlan Richardson; Steven N Austad; Kathleen Fischer
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-16       Impact factor: 6.053

6.  Rapamycin extends murine lifespan but has limited effects on aging.

Authors:  Frauke Neff; Diana Flores-Dominguez; Devon P Ryan; Marion Horsch; Susanne Schröder; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Lillian Garrett; Wolfgang Hans; Moritz M Hettich; Richard Holtmeier; Sabine M Hölter; Kristin Moreth; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Birgit Rathkolb; Jan Rozman; Beatrix Naton; Rainer Ordemann; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Gerhard Ehninger; Jochen Graw; Heinz Höfler; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Jörg Stypmann; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Helmut Fuchs; Valérie Gailus-Durner; Martin Hrabe de Angelis; Dan Ehninger
Journal:  J Clin Invest       Date:  2013-07-25       Impact factor: 14.808

7.  Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

Authors:  Fresnida J Ramos; Steven C Chen; Michael G Garelick; Dao-Fu Dai; Chen-Yu Liao; Katherine H Schreiber; Vivian L MacKay; Elroy H An; Randy Strong; Warren C Ladiges; Peter S Rabinovitch; Matt Kaeberlein; Brian K Kennedy
Journal:  Sci Transl Med       Date:  2012-07-25       Impact factor: 17.956

8.  Rapamycin slows aging in mice.

Authors:  John E Wilkinson; Lisa Burmeister; Susan V Brooks; Chi-Chao Chan; Sabrina Friedline; David E Harrison; James F Hejtmancik; Nancy Nadon; Randy Strong; Lauren K Wood; Maria A Woodward; Richard A Miller
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

9.  New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.

Authors:  Maria Comas; Ilia Toshkov; Karen K Kuropatwinski; Olga B Chernova; Alexander Polinsky; Mikhail V Blagosklonny; Andrei V Gudkov; Marina P Antoch
Journal:  Aging (Albany NY)       Date:  2012-10       Impact factor: 5.682

10.  Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.

Authors:  Carolina B Livi; Rulon L Hardman; Barbara A Christy; Sherry G Dodds; Diane Jones; Charnae Williams; Randy Strong; Alex Bokov; Martin A Javors; Yuji Ikeno; Gene Hubbard; Paul Hasty; Zelton Dave Sharp
Journal:  Aging (Albany NY)       Date:  2013-02       Impact factor: 5.682
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  13 in total

1.  How healthy is the healthspan concept?

Authors:  Matt Kaeberlein
Journal:  Geroscience       Date:  2018-08-06       Impact factor: 7.713

2.  Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Authors:  Arlan Richardson; Kathleen E Fischer; John R Speakman; Rafael de Cabo; Sarah J Mitchell; Charlotte A Peterson; Peter Rabinovitch; Ying A Chiao; George Taffet; Richard A Miller; René C Rentería; James Bower; Donald K Ingram; Warren C Ladiges; Yuji Ikeno; Felipe Sierra; Steven N Austad
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2015-08-22       Impact factor: 6.053

Review 3.  The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.

Authors:  M Kaeberlein
Journal:  Vet Pathol       Date:  2015-06-15       Impact factor: 2.221

Review 4.  Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions.

Authors:  Jordan B Jahrling; Remi-Martin Laberge
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

5.  Prevention of carcinogen and inflammation-induced dermal cancer by oral rapamycin includes reducing genetic damage.

Authors:  Vinh Dao; Srilakshmi Pandeswara; Yang Liu; Vincent Hurez; Sherry Dodds; Danielle Callaway; Aijie Liu; Paul Hasty; Zelton D Sharp; Tyler J Curiel
Journal:  Cancer Prev Res (Phila)       Date:  2015-03-03

6.  eRapa restores a normal life span in a FAP mouse model.

Authors:  Paul Hasty; Carolina B Livi; Sherry G Dodds; Diane Jones; Randy Strong; Martin Javors; Kathleen E Fischer; Lauren Sloane; Kruthi Murthy; Gene Hubbard; Lishi Sun; Vincent Hurez; Tyler J Curiel; Zelton Dave Sharp
Journal:  Cancer Prev Res (Phila)       Date:  2013-11-26

Review 7.  Sirtuins: guardians of mammalian healthspan.

Authors:  William Giblin; Mary E Skinner; David B Lombard
Journal:  Trends Genet       Date:  2014-05-28       Impact factor: 11.639

Review 8.  Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

Authors:  Surinder Kumar; David B Lombard
Journal:  F1000Res       Date:  2016-03-29

Review 9.  The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases.

Authors:  Matthew Redmann; Victor Darley-Usmar; Jianhua Zhang
Journal:  Aging Dis       Date:  2016-03-15       Impact factor: 6.745

Review 10.  Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders.

Authors:  Camilla Evangelisti; Vittoria Cenni; Giovanna Lattanzi
Journal:  Br J Clin Pharmacol       Date:  2016-05-18       Impact factor: 4.335
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