Literature DB >> 24060850

Hepatitis C: a mouse at the end of the tunnel.

Marco Binder1, Ralf Bartenschlager.   

Abstract

Since its discovery in 1989, researchers strive after a small animal model for Hepatitis C virus infection, so far with very limited success. A study recently published in Nature now for the first time reports the recapitulation of the complete life cycle of this virus in inbred mice with a functional adaptive immune system.

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Year:  2013        PMID： 24060850      PMCID： PMC3847570          DOI： 10.1038/cr.2013.132

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  10 in total

1.  Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122.

Authors:  Liang-Tzung Lin; Ryan S Noyce; Tram N Q Pham; Joyce A Wilson; Gary R Sisson; Thomas I Michalak; Karen L Mossman; Christopher D Richardson
Journal:  J Virol       Date:  2010-06-30       Impact factor: 5.103

2.  Production of infectious hepatitis C virus in tissue culture from a cloned viral genome.

Authors:  Takaji Wakita; Thomas Pietschmann; Takanobu Kato; Tomoko Date; Michiko Miyamoto; Zijiang Zhao; Krishna Murthy; Anja Habermann; Hans-Georg Kräusslich; Masashi Mizokami; Ralf Bartenschlager; T Jake Liang
Journal:  Nat Med       Date:  2005-06-12       Impact factor: 53.440

3.  Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities.

Authors:  Kyung-Soo Chang; Zhaohui Cai; Chen Zhang; Ganes C Sen; Bryan R G Williams; Guangxiang Luo
Journal:  J Virol       Date:  2006-08       Impact factor: 5.103

4.  Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line.

Authors:  V Lohmann; F Körner; J Koch; U Herian; L Theilmann; R Bartenschlager
Journal:  Science       Date:  1999-07-02       Impact factor: 47.728

5.  A genetically humanized mouse model for hepatitis C virus infection.

Authors:  Marcus Dorner; Joshua A Horwitz; Justin B Robbins; Walter T Barry; Qian Feng; Kathy Mu; Christopher T Jones; John W Schoggins; Maria Teresa Catanese; Dennis R Burton; Mansun Law; Charles M Rice; Alexander Ploss
Journal:  Nature       Date:  2011-06-08       Impact factor: 49.962

6.  Completion of the entire hepatitis C virus life cycle in genetically humanized mice.

Authors:  Marcus Dorner; Joshua A Horwitz; Bridget M Donovan; Rachael N Labitt; William C Budell; Tamar Friling; Alexander Vogt; Maria Teresa Catanese; Takashi Satoh; Taro Kawai; Shizuo Akira; Mansun Law; Charles M Rice; Alexander Ploss
Journal:  Nature       Date:  2013-07-31       Impact factor: 49.962

7.  Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model.

Authors:  Juandy Jo; Ulrike Aichele; Nadine Kersting; Rahel Klein; Peter Aichele; Emmanuel Bisse; Andrew K Sewell; Hubert E Blum; Ralf Bartenschlager; Volker Lohmann; Robert Thimme
Journal:  Gastroenterology       Date:  2008-12-13       Impact factor: 22.682

8.  Human occludin is a hepatitis C virus entry factor required for infection of mouse cells.

Authors:  Alexander Ploss; Matthew J Evans; Valeriya A Gaysinskaya; Maryline Panis; Hana You; Ype P de Jong; Charles M Rice
Journal:  Nature       Date:  2009-01-28       Impact factor: 49.962

9.  Hepatitis C virus infection and related liver disease: the quest for the best animal model.

Authors:  Laurent Mailly; Eric Robinet; Philip Meuleman; Thomas F Baumert; Mirjam B Zeisel
Journal:  Front Microbiol       Date:  2013-07-26       Impact factor: 5.640

Review 10.  Hepatitis C virus RNA replication.

Authors:  Volker Lohmann
Journal:  Curr Top Microbiol Immunol       Date:  2013       Impact factor: 4.291
  10 in total

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