Literature DB >> 24060699

Gut hormones as therapeutic agents in treatment of diabetes and obesity.

Tricia Tan1, Stephen Bloom.   

Abstract

Obesity and Type 2 Diabetes Mellitus (T2DM) present an ever-increasing threat to global health. Although bariatric surgery is an effective treatment, it cannot be applied to the vast majority of patients. The beneficial effects of bariatric surgery are related to complex alterations in the secretion of gut hormones. By recapitulation of the changes of gut hormone secretion after bariatric surgery, drugs based on gut hormones represent an exciting possibility for the treatment of T2DM and obesity. We review the rapidly emerging role of GLP-1 based treatments as well as the future for new drugs based on other gut hormones such as GIP, ghrelin, oxyntomodulin and peptide YY.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24060699     DOI： 10.1016/j.coph.2013.09.005

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  15 in total

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Journal:  Diabetologia       Date:  2015-12-12       Impact factor: 10.122

10.  Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats.

Authors:  Yu-Wen Yu; Tsung-Hsun Hsieh; Kai-Yun Chen; John Chung-Che Wu; Barry J Hoffer; Nigel H Greig; Yazhou Li; Jing-Huei Lai; Cheng-Fu Chang; Jia-Wei Lin; Yu-Hsin Chen; Liang-Yo Yang; Yung-Hsiao Chiang
Journal:  J Neurotrauma       Date:  2016-05-09       Impact factor: 5.269
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