Literature DB >> 24059320

Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus.

Rizwanul Haque, Aamir Nazir1.   

Abstract

Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer's disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer's disease and the approaches that make IDE a potential target, are discussed.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24059320     DOI： 10.2174/18715273113126660139

Source DB:  PubMed          Journal:  CNS Neurol Disord Drug Targets        ISSN： 1871-5273            Impact factor:   4.388


  20 in total

1.  Vibrio vulnificus Secretes an Insulin-degrading Enzyme That Promotes Bacterial Proliferation in Vivo.

Authors:  In Hwang Kim; Ik-Jung Kim; Yancheng Wen; Na-Young Park; Jinyoung Park; Keun-Woo Lee; Ara Koh; Ji-Hyun Lee; Seung-Hoi Koo; Kun-Soo Kim
Journal:  J Biol Chem       Date:  2015-06-03       Impact factor: 5.157

Review 2.  Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.

Authors:  Subbiah Pugazhenthi; Limei Qin; P Hemachandra Reddy
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2016-05-06       Impact factor: 5.187

3.  Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice.

Authors:  Lu Gan; Zi-jun Meng; Ri-bo Xiong; Jin-qiang Guo; Xiao-cui Lu; Zhi-wei Zheng; Yan-ping Deng; Bing-de Luo; Fei Zou; Hua Li
Journal:  Acta Pharmacol Sin       Date:  2015-04-20       Impact factor: 6.150

4.  Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms.

Authors:  Sarah Patrick; Rachel Corrigan; John Grizzanti; Megan Mey; Jeff Blair; Merce Pallas; Antonio Camins; Hyoung-Gon Lee; Gemma Casadesus
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

Review 5.  Contributive Role of Hyperglycemia and Hypoglycemia Towards the Development of Alzheimer's Disease.

Authors:  Riya Chakrabarty; Sumaira Yousuf; Mahendra P Singh
Journal:  Mol Neurobiol       Date:  2022-05-03       Impact factor: 5.590

6.  CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation.

Authors:  Melissa J Alldred; Helen M Chao; Sang Han Lee; Judah Beilin; Brian E Powers; Eva Petkova; Barbara J Strupp; Stephen D Ginsberg
Journal:  Hippocampus       Date:  2018-02-12       Impact factor: 3.899

7.  Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention.

Authors:  Jeriel Thomas-Richard Keeney; Shaher Ibrahimi; Liqin Zhao
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

8.  Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.

Authors:  Bikash R Sahoo; Pritam Kumar Panda; Wenguang Liang; Wei-Jen Tang; Rajeev Ahuja; Ayyalusamy Ramamoorthy
Journal:  J Mol Biol       Date:  2021-04-16       Impact factor: 6.151

Review 9.  Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.

Authors:  Natalia N Nalivaeva; Nikolai D Belyaev; Caroline Kerridge; Anthony J Turner
Journal:  Front Aging Neurosci       Date:  2014-09-17       Impact factor: 5.750

10.  Chromium-Insulin Reduces Insulin Clearance and Enhances Insulin Signaling by Suppressing Hepatic Insulin-Degrading Enzyme and Proteasome Protein Expression in KKAy Mice.

Authors:  Zhong Q Wang; Yongmei Yu; Xian H Zhang; James Komorowski
Journal:  Front Endocrinol (Lausanne)       Date:  2014-07-07       Impact factor: 5.555
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.