Effect of thiol-containing monomer on the preparation of temperature-sensitive hydrogel microspheres.

The main objective of this study is to prepare, thermally, sensitive microgel particles bearing thiol groups via precipitation polymerization of N-isopropylacrylamide (NIPAM), methylenebisacrylamide (MBA) and vinylbenzylisothiouronium chloride (VBIC) using 2-2'-azobis(2-amidinopropane)-dihydrochloride (V50) as initiator. The influence of various parameters has been investigated as a systematic study to point out the role of each reactant on polymerization conversion, and consequently, on particles and water-soluble polymer formation. The final microgel particles were characterized with respect to particle size and swelling ability. The aim of this paper is to complete our first short communication; Macromolecular symposia, 2000. 150: p. 283-290.