Literature DB >> 24057181

Analyze association of the progesterone receptor gene polymorphism PROGINS with ovarian cancer risk.

Cunzhong Yuan1, Cunfang Wang, Xiaoyan Liu, Beihua Kong.   

Abstract

Results conflict on the association between progesterone receptor gene (PRG) polymorphism PROGINS and ovarian cancer risk, despite wide-ranging investigations. We therefore performed a meta-analysis of 4,285 ovarian cancer cases and 6,257 controls from 11 published case-control studies. The strength of association between PROGINS polymorphism and ovarian cancer susceptibility was assessed using pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs). The results suggest no significant associations exist between PROGINS polymorphisms and ovarian cancer risk in overall comparisons in all genetic models (T2T2 vs. T1T1: OR = 1.37, 95 % CI = 0.89-2.12, P = 0.15; T1T2 vs. T1T1:OR = 1.09, 95 % CI = 0.88-1.35, P = 0.41; T1T2 + T2T2 vs. T1T1:OR = 1.15, 95 % CI = 0.94-1.40, P = 0.17; T2T2 vs. T1 T1 + T1T2:OR = 1.34, 95 % CI = 0.87-2.07, P = 0.18). In conclusion, the results of this meta-analysis indicate that the PRG polymorphism PROGINS is not associated with ovarian cancer risk when multiple ethnic groups or regions were considered overall.

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Year:  2013        PMID： 24057181     DOI： 10.1007/s11033-013-2709-x

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  45 in total

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Review 3.  MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis.

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4.  A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

Authors:  Ellen L Goode; Georgia Chenevix-Trench; Honglin Song; Susan J Ramus; Maria Notaridou; Kate Lawrenson; Martin Widschwendter; Robert A Vierkant; Melissa C Larson; Susanne K Kjaer; Michael J Birrer; Andrew Berchuck; Joellen Schildkraut; Ian Tomlinson; Lambertus A Kiemeney; Linda S Cook; Jacek Gronwald; Montserrat Garcia-Closas; Martin E Gore; Ian Campbell; Alice S Whittemore; Rebecca Sutphen; Catherine Phelan; Hoda Anton-Culver; Celeste Leigh Pearce; Diether Lambrechts; Mary Anne Rossing; Jenny Chang-Claude; Kirsten B Moysich; Marc T Goodman; Thilo Dörk; Heli Nevanlinna; Roberta B Ness; Thorunn Rafnar; Claus Hogdall; Estrid Hogdall; Brooke L Fridley; Julie M Cunningham; Weiva Sieh; Valerie McGuire; Andrew K Godwin; Daniel W Cramer; Dena Hernandez; Douglas Levine; Karen Lu; Edwin S Iversen; Rachel T Palmieri; Richard Houlston; Anne M van Altena; Katja K H Aben; Leon F A G Massuger; Angela Brooks-Wilson; Linda E Kelemen; Nhu D Le; Anna Jakubowska; Jan Lubinski; Krzysztof Medrek; Anne Stafford; Douglas F Easton; Jonathan Tyrer; Kelly L Bolton; Patricia Harrington; Diana Eccles; Ann Chen; Ashley N Molina; Barbara N Davila; Hector Arango; Ya-Yu Tsai; Zhihua Chen; Harvey A Risch; John McLaughlin; Steven A Narod; Argyrios Ziogas; Wendy Brewster; Aleksandra Gentry-Maharaj; Usha Menon; Anna H Wu; Daniel O Stram; Malcolm C Pike; Jonathan Beesley; Penelope M Webb; Xiaoqing Chen; Arif B Ekici; Falk C Thiel; Matthias W Beckmann; Hannah Yang; Nicolas Wentzensen; Jolanta Lissowska; Peter A Fasching; Evelyn Despierre; Frederic Amant; Ignace Vergote; Jennifer Doherty; Rebecca Hein; Shan Wang-Gohrke; Galina Lurie; Michael E Carney; Pamela J Thompson; Ingo Runnebaum; Peter Hillemanns; Matthias Dürst; Natalia Antonenkova; Natalia Bogdanova; Arto Leminen; Ralf Butzow; Tuomas Heikkinen; Kari Stefansson; Patrick Sulem; Sören Besenbacher; Thomas A Sellers; Simon A Gayther; Paul D P Pharoah
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5.  Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.

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Journal:  Nat Genet       Date:  2010-04-18       Impact factor: 38.330

6.  No association of a 306-bp insertion polymorphism in the progesterone receptor gene with ovarian and breast cancer.

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Journal:  Mol Endocrinol       Date:  1994-10

Review 8.  Progesterone biosynthesis and action in the developing neuron.

Authors:  Kazuyoshi Tsutsui
Journal:  Endocrinology       Date:  2008-02-28       Impact factor: 4.736

9.  Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.

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10.  Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.

Authors:  C L Pearce; A H Wu; S A Gayther; A E Bale; P A Beck; J Beesley; S Chanock; D W Cramer; R DiCioccio; R Edwards; Z S Fredericksen; M Garcia-Closas; E L Goode; A C Green; L C Hartmann; E Hogdall; S K Kjaer; J Lissowska; V McGuire; F Modugno; K Moysich; R B Ness; S J Ramus; H A Risch; T A Sellers; H Song; D O Stram; K L Terry; P M Webb; D C Whiteman; A S Whittemore; W Zheng; P D P Pharoah; G Chenevix-Trench; M C Pike; J Schildkraut; A Berchuck
Journal:  Br J Cancer       Date:  2008-01-22       Impact factor: 7.640
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2.  Analysis of the association between the XRCC2 rs3218536 polymorphism and ovarian cancer risk.

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3.  Mutations in the Progesterone Receptor (PROGINS) May Reduce the Symptoms of Acute Hepatitis E and Protect Against Infection.

Authors:  Pedro López-López; Antonio Rivero-Juarez; Mario Frias; Isabel Machuca; Javier Caballero-Gómez; Israel Olivas; Angela Camacho; María de Los Angeles Risalde; Ignacio García-Bocanegra; Antonio Rivero
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4.  Progesterone receptor gene serves as a prognostic biomarker associated with immune infiltration in gastric cancer: a bioinformatics analysis.

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