Literature DB >> 24056874

Inducible control of gene expression with destabilized Cre.

Richard Sando1, Karsten Baumgaertel, Simon Pieraut, Nina Torabi-Rander, Thomas J Wandless, Mark Mayford, Anton Maximov.   

Abstract

Acute manipulation of gene and protein function in the brain is essential for understanding the mechanisms of nervous system development, plasticity and information processing. Here we describe a technique based on a destabilized Cre recombinase (DD-Cre) whose activity is controlled by the antibiotic trimethoprim (TMP). We show that DD-Cre triggers rapid TMP-dependent recombination of loxP-flanked ('floxed') alleles in mouse neurons in vivo and validate the use of this system for neurobehavioral research.

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Year:  2013        PMID： 24056874      PMCID： PMC3947879          DOI： 10.1038/nmeth.2640

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  26 in total

1.  Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity.

Authors:  T S Benice; A Rizk; S Kohama; T Pfankuch; J Raber
Journal:  Neuroscience       Date:  2005-12-05       Impact factor: 3.590

2.  Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons.

Authors:  Alla Y Karpova; Dougal G R Tervo; Noah W Gray; Karel Svoboda
Journal:  Neuron       Date:  2005-12-08       Impact factor: 17.173

3.  Remote control of neuronal activity with a light-gated glutamate receptor.

Authors:  Stephanie Szobota; Pau Gorostiza; Filippo Del Bene; Claire Wyart; Doris L Fortin; Kathleen D Kolstad; Orapim Tulyathan; Matthew Volgraf; Rika Numano; Holly L Aaron; Ethan K Scott; Richard H Kramer; John Flannery; Herwig Baier; Dirk Trauner; Ehud Y Isacoff
Journal:  Neuron       Date:  2007-05-24       Impact factor: 17.173

4.  Inducible and reversible gene expression with the rtTA system for the study of memory.

Authors:  I M Mansuy; D G Winder; T M Moallem; M Osman; M Mayford; R D Hawkins; E R Kandel
Journal:  Neuron       Date:  1998-08       Impact factor: 17.173

5.  A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.

Authors:  Laura A Banaszynski; Ling-Chun Chen; Lystranne A Maynard-Smith; A G Lisa Ooi; Thomas J Wandless
Journal:  Cell       Date:  2006-09-08       Impact factor: 41.582

6.  Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.

Authors:  C A Barnes
Journal:  J Comp Physiol Psychol       Date:  1979-02

7.  Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells.

Authors:  Irma S Lantinga-van Leeuwen; Wouter N Leonhard; Annemieke van de Wal; Martijn H Breuning; Sjef Verbeek; Emile de Heer; Dorien J M Peters
Journal:  Genesis       Date:  2006-05       Impact factor: 2.487

8.  Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase.

Authors:  P S Danielian; D Muccino; D H Rowitch; S K Michael; A P McMahon
Journal:  Curr Biol       Date:  1998-12-03       Impact factor: 10.834

9.  Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning.

Authors:  Toshiaki Nakashiba; Jennie Z Young; Thomas J McHugh; Derek L Buhl; Susumu Tonegawa
Journal:  Science       Date:  2008-01-24       Impact factor: 47.728

10.  Pharmacokinetics of trimethoprim in the rat.

Authors:  Y H Tu; L V Allen; V M Fiorica; D D Albers
Journal:  J Pharm Sci       Date:  1989-07       Impact factor: 3.534
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  45 in total

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Authors:  Rebekah C Evans; Manhua Zhu; Zayd M Khaliq
Journal:  J Neurosci       Date:  2017-03-06       Impact factor: 6.167

Review 2.  Molecular Genetic Strategies in the Study of Corticohippocampal Circuits.

Authors:  Christopher C Angelakos; Ted Abel
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-07-01       Impact factor: 10.005

3.  Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse.

Authors:  Huiying Li; Qiansen Zhang; Yiran Gu; Yingyin Wu; Yamei Wang; Liren Wang; Shijie Feng; Yaqiang Hu; Yansen Zheng; Yongmei Li; Haifeng Ye; Bin Zhou; Longnian Lin; Mingyao Liu; Huaiyu Yang; Dali Li
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-14       Impact factor: 11.205

4.  A photoactivatable Cre-loxP recombination system for optogenetic genome engineering.

Authors:  Fuun Kawano; Risako Okazaki; Masayuki Yazawa; Moritoshi Sato
Journal:  Nat Chem Biol       Date:  2016-10-10       Impact factor: 15.040

Review 5.  Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism.

Authors:  Russell P Goodman; Sarah E Calvo; Vamsi K Mootha
Journal:  J Biol Chem       Date:  2018-03-07       Impact factor: 5.157

Review 6.  Chemogenetic Tools for Causal Cellular and Neuronal Biology.

Authors:  Deniz Atasoy; Scott M Sternson
Journal:  Physiol Rev       Date:  2018-01-01       Impact factor: 37.312

7.  Experience-dependent remodeling of basket cell networks in the dentate gyrus.

Authors:  Simon Pieraut; Natalia Gounko; Richard Sando; Westley Dang; Elisabeth Rebboah; Satchidananda Panda; Linda Madisen; Hongkui Zeng; Anton Maximov
Journal:  Neuron       Date:  2014-10-01       Impact factor: 17.173

Review 8.  Towards an Understanding of Synapse Formation.

Authors:  Thomas C Südhof
Journal:  Neuron       Date:  2018-10-24       Impact factor: 17.173

9.  A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality.

Authors:  Tanya L Daigle; Linda Madisen; Travis A Hage; Matthew T Valley; Ulf Knoblich; Rylan S Larsen; Marc M Takeno; Lawrence Huang; Hong Gu; Rachael Larsen; Maya Mills; Alice Bosma-Moody; La' Akea Siverts; Miranda Walker; Lucas T Graybuck; Zizhen Yao; Olivia Fong; Thuc Nghi Nguyen; Emma Garren; Garreck H Lenz; Mariya Chavarha; Julie Pendergraft; James Harrington; Karla E Hirokawa; Julie A Harris; Philip R Nicovich; Medea J McGraw; Douglas R Ollerenshaw; Kimberly A Smith; Christopher A Baker; Jonathan T Ting; Susan M Sunkin; Jérôme Lecoq; Michael Z Lin; Edward S Boyden; Gabe J Murphy; Nuno M da Costa; Jack Waters; Lu Li; Bosiljka Tasic; Hongkui Zeng
Journal:  Cell       Date:  2018-07-12       Impact factor: 41.582

10.  Adult-Onset Deletion of β-Catenin in (10kb)Dmp1-Expressing Cells Prevents Intermittent PTH-Induced Bone Gain.

Authors:  Rajendra Kedlaya; Kyung Shin Kang; Jung Min Hong; Vidya Bettagere; Kyung-Eun Lim; Daniel Horan; Paola Divieti-Pajevic; Alexander G Robling
Journal:  Endocrinology       Date:  2016-06-02       Impact factor: 4.736
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