OBJECTIVE: The term 'source of HIV infections' has been referred to as the source of HIV transmission. It has also been interpreted as the distribution of newly acquired HIV infections across subgroups. We illustrate the importance of distinguishing the two interpretations for HIV prevention planning. METHODS: We used a dynamical model of heterosexual HIV transmission to simulate three HIV epidemics, and estimated the sources of HIV transmission (cumulative population attributable fraction) and the single-year distribution of new HIV infections. We focused an intervention guided by the largest transmission source versus the largest single-year distribution of new HIV infections, and compared the fraction of discounted HIV infections averted over 30 years. RESULTS: The single-year distribution of newly acquired HIV infections underestimated the source of HIV transmission in the long term, when the source was unprotected sex in high-risk groups. Under equivalent and finite resources, an intervention strategy directed by the long-term transmission source was shown to achieve a greater impact than a distribution-directed strategy, particularly in the long term. CONCLUSIONS: Impact of HIV prevention strategies may vary depending on whether they are directed by the long-term transmission source or by the distribution of new HIV infections. Caution is required when interpreting the 'source of HIV infections' to avoid misusing the distribution of new HIV infections in HIV prevention planning.
OBJECTIVE: The term 'source of HIV infections' has been referred to as the source of HIV transmission. It has also been interpreted as the distribution of newly acquired HIV infections across subgroups. We illustrate the importance of distinguishing the two interpretations for HIV prevention planning. METHODS: We used a dynamical model of heterosexual HIV transmission to simulate three HIV epidemics, and estimated the sources of HIV transmission (cumulative population attributable fraction) and the single-year distribution of new HIV infections. We focused an intervention guided by the largest transmission source versus the largest single-year distribution of new HIV infections, and compared the fraction of discounted HIV infections averted over 30 years. RESULTS: The single-year distribution of newly acquired HIV infections underestimated the source of HIV transmission in the long term, when the source was unprotected sex in high-risk groups. Under equivalent and finite resources, an intervention strategy directed by the long-term transmission source was shown to achieve a greater impact than a distribution-directed strategy, particularly in the long term. CONCLUSIONS: Impact of HIV prevention strategies may vary depending on whether they are directed by the long-term transmission source or by the distribution of new HIV infections. Caution is required when interpreting the 'source of HIV infections' to avoid misusing the distribution of new HIV infections in HIV prevention planning.
Authors: Elena Dragioti; Joaquim Radua; Marco Solmi; Celso Arango; Dominic Oliver; Samuele Cortese; Peter B Jones; Jae Il Shin; Christoph U Correll; Paolo Fusar-Poli Journal: Mol Psychiatry Date: 2022-04-28 Impact factor: 15.992
Authors: Carly A Comins; Sheree R Schwartz; Deliwe R Phetlhu; Vijayanand Guddera; Katherine Young; Jason E Farley; Nora West; Lauren Parmley; Elvin Geng; Chris Beyrer; David Dowdy; Sharmistha Mishra; Harry Hausler; Stefan Baral Journal: Res Nurs Health Date: 2019-01-15 Impact factor: 2.228
Authors: Sharmistha Mishra; Marie-Claude Boily; Sheree Schwartz; Chris Beyrer; James F Blanchard; Stephen Moses; Delivette Castor; Nancy Phaswana-Mafuya; Peter Vickerman; Fatou Drame; Michel Alary; Stefan D Baral Journal: Ann Epidemiol Date: 2016-06-15 Impact factor: 3.797
Authors: William X You; Carly A Comins; Brooke A Jarrett; Katherine Young; Vijayanand Guddera; Deliwe R Phetlhu; Ntambue Mulumba; Mfezi Mcingana; Harry Hausler; Stefan Baral; Sheree Schwartz Journal: Mhealth Date: 2020-04-05