Gwan Gyu Song1, Jae-Hoon Kim1, Young Ho Seo1, Sung Jae Choi1, Jong Dae Ji1, Young Ho Lee2. 1. Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea. 2. Division of Rheumatology, Department of Internal Medicine, Korea University, College of Medicine, Seoul, Republic of Korea. Electronic address: lyhcgh@korea.ac.kr.
Abstract
OBJECTIVE: This study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). METHODS: A meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1RN) polymorphisms and SLE. RESULTS: A total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A -889 T allele in the overall population and Europeans (OR = 0.858, 95% CI = 0.737-0.986, p = 0.032; OR = 0.827, 95% CI = 0.687-0.994, p = 0.043). Meta-analysis of the IL1RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN*2 = 1.539, 95% CI = 1.266-1.871, p = 1.5 × 10(-2)) and in Europeans and Asians (OR = 1.483, 95% CI = 1.187-1.852, p = 0.001; OR = 1.787, 95% CI = 1.167-2.736, p=0.008). No associations were found between SLE and the IL1B -511 C/T, 3953 C/T, and IL1A +4845 G/T polymorphisms. CONCLUSIONS: This meta-analysis suggests IL1A -889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1RN*2 allele is associated with susceptibility to SLE in Europeans and Asians.
OBJECTIVE: This study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). METHODS: A meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1RN) polymorphisms and SLE. RESULTS: A total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A -889 T allele in the overall population and Europeans (OR = 0.858, 95% CI = 0.737-0.986, p = 0.032; OR = 0.827, 95% CI = 0.687-0.994, p = 0.043). Meta-analysis of the IL1RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN*2 = 1.539, 95% CI = 1.266-1.871, p = 1.5 × 10(-2)) and in Europeans and Asians (OR = 1.483, 95% CI = 1.187-1.852, p = 0.001; OR = 1.787, 95% CI = 1.167-2.736, p=0.008). No associations were found between SLE and the IL1B -511 C/T, 3953 C/T, and IL1A+4845 G/T polymorphisms. CONCLUSIONS: This meta-analysis suggests IL1A-889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1RN*2 allele is associated with susceptibility to SLE in Europeans and Asians.
Authors: Jeremy S Tilstra; Shinu John; Rachael A Gordon; Claire Leibler; Michael Kashgarian; Sheldon Bastacky; Kevin M Nickerson; Mark J Shlomchik Journal: J Clin Invest Date: 2020-06-01 Impact factor: 14.808
Authors: Samantha Slight-Webb; Rufei Lu; Lauren L Ritterhouse; Melissa E Munroe; Holden T Maecker; Charles G Fathman; Paul J Utz; Joan T Merrill; Joel M Guthridge; Judith A James Journal: Arthritis Rheumatol Date: 2016-10 Impact factor: 10.995