| Literature DB >> 24055369 |
Xiao-Hua Yu1, Zhi-Bin Tang2, Li-Jing Liu3, Hong Qian3, Shi-Lin Tang2, Da-Wei Zhang4, Guo-Ping Tian5, Chao-Ke Tang6.
Abstract
Apelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation. Growing evidence shows that apelin/APJ system functions as a critical mediator of cardiovascular homeostasis and is involved in the pathophysiology of cardiovascular diseases. Targeting apelin/APJ axis produces protection against cardiovascular diseases. In the current review we have summarized recent data concerning the role and therapeutic potential of apelin/APJ in several major cardiovascular diseases. An increased understanding of the cardiovascular actions of apelin/APJ system will help to develop novel therapeutic interventions for cardiovascular diseases.Entities:
Keywords: ABCA1; ACAT1; APJ; ATP-binding cassette transporter A1; Ang II; Ang-1; Apelin; Atherosclerosis; BMP; BNP; CAD; COX-2; FGF2; GSK; HDAC; HIF-1α; Heart failure; Hypertension; ICAM-1; IRS1; JNK; MCP-1; MEF2; MIRI; NO; PAH; PDGF-BB; PGE2; PI3K; PKB; PKC; PPAR response elements; PPREs; TGF-β; TNF-α; VCAM-1; VEGFA; VSMC; acyl coenzyme A:cholesterol acyltransferase-1; angiopoietin-1; angiotensin II; apo E; apolipoprotein E; bone morphogenic protein; brain natriuretic peptide; c-Jun N-terminal kinase; coronary heart disease; cyclooxygenase-2; fibroblast growth factor 2; glycogen synthase kinase; histone deacetylase; hypoxia-inducible factor 1α; insulin receptor substrate 1; intercellular adhesion molecule-1; monocyte chemoattractant protein-1; myocardial ischemia–reperfusion injury; myocyte enhancer factor 2; nitric oxide; phosphatidylinositol 3-kinase; platelet-derived growth factor-BB; prostaglandin E2; protein kinase B; protein kinase C; pulmonary arterial hypertension; transforming growth factor-β; tumor necrosis factor-α; vascular cell adhesion molecule-1; vascular endothelial growth factor type A; vascular smooth muscle cell
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Year: 2013 PMID： 24055369 DOI： 10.1016/j.cca.2013.09.001
Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786