Literature DB >> 24055287

Structure-activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery.

Defu Zhi1, Shubiao Zhang, Farooq Qureshi, Yinan Zhao, Shaohui Cui, Bing Wang, Huiying Chen, Baoling Yang, Defeng Zhao.   

Abstract

A novel series of carbamate-linked cationic lipids containing hydroxyl headgroup were synthesized and included in formulations for transfection assays. The DNA-lipid complexes were characterized for their ability to bind DNA, their size, ζ-potential and cytotoxicity. Compared with our previously reported cationic transfection lipid DDCDMA lacking the hydroxyl group and the commercially available, these cationic liposomes exhibited relatively higher transfection efficiency.
Copyright © 2013 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Carbamate-linked cationic lipids; Cytotoxicity; Gene delivery; Hydroxyl group; Transfection efficiency

Mesh：

Substances：

Year:  2013        PMID： 24055287     DOI： 10.1016/j.colsurfb.2013.08.040

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


  2 in total

Review 1.  Tumor immunotherapy and multi-mode therapies mediated by medical imaging of nanoprobes.

Authors:  Yang Xuan; Meng Guan; Shubiao Zhang
Journal:  Theranostics       Date:  2021-05-25       Impact factor: 11.556

2.  Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy.

Authors:  Chuanmin Zhang; Yinan Zhao; Enxia Zhang; Meilin Jiang; Defu Zhi; Huiying Chen; Shaohui Cui; Yuhong Zhen; Jingnan Cui; Shubiao Zhang
Journal:  Drug Deliv       Date:  2020-12       Impact factor: 6.419
  2 in total

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