Literature DB >> 2405488

Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae.

J Field1, H P Xu, T Michaeli, R Ballester, P Sass, M Wigler, J Colicelli.   

Abstract

The interaction between RAS proteins and adenylyl cyclase was studied by using dominant interfering mutations of adenylyl cyclase from the yeast Saccharomyces cerevisiae. RAS proteins activate adenylyl cyclase in this organism. A plasmid expressing a catalytically inactive adenylyl cyclase was found to interfere dominantly with this activation. The interfering region mapped to the leucine-rich repeat region of adenylyl cyclase, which is homologous to domains present in several other proteins and is thought to participate in protein-protein interactions.

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Year:  1990        PMID： 2405488     DOI： 10.1126/science.2405488

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  47 in total

1.  Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.

Authors:  R J Deshaies; R Schekman
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

2.  Novel brain-specific bovine cDNA for a developmentally regulated mRNA encoding a putative new member of the leucine-rich glycoprotein (LRG) family.

Authors:  E C Tan; L Lim
Journal:  Neurochem Res       Date:  1992-09       Impact factor: 3.996

3.  The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae.

Authors:  Yelena V Budovskaya; Joseph S Stephan; Fulvio Reggiori; Daniel J Klionsky; Paul K Herman
Journal:  J Biol Chem       Date:  2004-03-11       Impact factor: 5.157

4.  Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation.

Authors:  M L Cutler; R H Bassin; L Zanoni; N Talbot
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

5.  A gene from the VSG expression site of Trypanosoma brucei encodes a protein with both leucine-rich repeats and a putative zinc finger.

Authors:  P Revelard; S Lips; E Pays
Journal:  Nucleic Acids Res       Date:  1990-12-25       Impact factor: 16.971

6.  Suppression of survival signalling pathways by the phosphatase PHLPP.

Authors:  Audrey K O'Neill; Matthew J Niederst; Alexandra C Newton
Journal:  FEBS J       Date:  2012-03-16       Impact factor: 5.542

7.  The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins.

Authors:  B L Smiley; A W Stadnyk; P J Myler; K Stuart
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

8.  Antagonistic interactions between the cAMP-dependent protein kinase and Tor signaling pathways modulate cell growth in Saccharomyces cerevisiae.

Authors:  Vidhya Ramachandran; Paul K Herman
Journal:  Genetics       Date:  2010-11-15       Impact factor: 4.562

9.  Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase.

Authors:  J Colicelli; J Field; R Ballester; N Chester; D Young; M Wigler
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

10.  Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

Authors:  J Colicelli; C Nicolette; C Birchmeier; L Rodgers; M Riggs; M Wigler
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205
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