OBJECTIVES: To evaluate the prevalence, distribution and association of HPV with histological pattern of worse prognosis of penile cancer, in order to evaluate its predictive value of inguinal metastasis, as well as evaluation of other previous reported prognostic factors. MATERIAL AND METHODS: Tumor samples of 82 patients with penile carcinoma were tested in order to establish the prevalence and distribution of genotypic HPV using PCR. HPV status was correlated to histopathological factors and the presence of inguinal mestastasis. The influence of several histological characteristics was also correlated to inguinal disease-free survival. RESULTS: Follow-up varied from 1 to 71 months (median 22 months). HPV DNA was identified in 60.9% of sample, with higher prevalence of types 11 and 6 (64% and 32%, respectively). There was no significant correlation of the histological characteristics of worse prognosis of penile cancer with HPV status. Inguinal disease-free survival in 5 years did also not show HPV status influence (p = 0.45). The only independent pathologic factors of inguinal metastasis were: stage T ≥ T1b-T4 (p = 0.02), lymphovascular invasion (p = 0.04) and infiltrative invasion (p = 0.03). CONCLUSIONS: HPV status and distribution had shown no correlation with worse prognosis of histological aspects, or predictive value for lymphatic metastasis in penile carcinoma.
OBJECTIVES: To evaluate the prevalence, distribution and association of HPV with histological pattern of worse prognosis of penile cancer, in order to evaluate its predictive value of inguinal metastasis, as well as evaluation of other previous reported prognostic factors. MATERIAL AND METHODS: Tumor samples of 82 patients with penile carcinoma were tested in order to establish the prevalence and distribution of genotypic HPV using PCR. HPV status was correlated to histopathological factors and the presence of inguinal mestastasis. The influence of several histological characteristics was also correlated to inguinal disease-free survival. RESULTS: Follow-up varied from 1 to 71 months (median 22 months). HPV DNA was identified in 60.9% of sample, with higher prevalence of types 11 and 6 (64% and 32%, respectively). There was no significant correlation of the histological characteristics of worse prognosis of penile cancer with HPV status. Inguinal disease-free survival in 5 years did also not show HPV status influence (p = 0.45). The only independent pathologic factors of inguinal metastasis were: stage T ≥ T1b-T4 (p = 0.02), lymphovascular invasion (p = 0.04) and infiltrative invasion (p = 0.03). CONCLUSIONS: HPV status and distribution had shown no correlation with worse prognosis of histological aspects, or predictive value for lymphatic metastasis in penile carcinoma.
Authors: Siraj M Ali; Sumanta K Pal; Kai Wang; Norma A Palma; Eric Sanford; Mark Bailey; Jie He; Julia A Elvin; Juliann Chmielecki; Rachel Squillace; Edward Dow; Deborah Morosini; Jamie Buell; Roman Yelensky; Doron Lipson; Garrett M Frampton; Peter Howley; Jeffrey S Ross; Philip J Stephens; Vincent A Miller Journal: Oncologist Date: 2015-12-15
Authors: Isaura Danielli Borges de Sousa; Flávia Castello Branco Vidal; João Paulo Castello Branco Vidal; George Castro Figueira de Mello; Maria do Desterro Soares Brandão Nascimento; Luciane Maria Oliveira Brito Journal: BMC Urol Date: 2015-02-24 Impact factor: 2.264
Authors: Julie Steinestel; Andreas Al Ghazal; Annette Arndt; Thomas J Schnoeller; Andres J Schrader; Peter Moeller; Konrad Steinestel Journal: BMC Cancer Date: 2015-04-03 Impact factor: 4.430
Authors: Lyriane Apolinário de Araújo; Adriano Augusto Peclat De Paula; Hellen da Silva Cintra de Paula; Jessica Enocêncio Porto Ramos; Brunna Rodrigues de Oliveira; Keila Patrícia Almeida De Carvalho; Rafael Alves Guimarães; Rita de Cássia Gonçalves de Alencar; Eliza Carla Barroso Duarte; Silvia Helena Rabelo Santos; Vera Aparecida Saddi; Megmar Aparecida Dos Santos Carneiro Journal: PLoS One Date: 2018-06-27 Impact factor: 3.240