| Literature DB >> 24053818 |
Yongmei Yang1, Peifang Liu, Lixia Chen, Zhaojun Liu, Huixue Zhang, Jianjian Wang, Xuesong Sun, Weiqi Zhong, Na Wang, Kuo Tian, Jingshun Zhao.
Abstract
An araban type polysaccharide (GBPw) was purified from the leaves of Ginkgo biloba. The present study aimed to investigate the protective effects of GBPw on focal ischemia/reperfusion (I/R) injury in rat brain. The results of this study demonstrated that GBPw had a positive effect on the rat brain when administered 7 days before focal cerebral I/R injury. This effect was evident with the improvements in neurological deficits, reduction in infarct volume, MDA content and the levels of pro-inflammatory cytokines (TNF-α and IL-1β), and elevation in the SOD and MPO activities and the levels of anti-inflammatory cytokine (IL-10). Thus, the beneficial effects of GBPw on cerebral I/R injury may result from the reduction of oxidative stress and the inhibition of NO production and inflammation induced by I/R. The neuroprotective effects of GBPw supplement may have potential implication in the future for prevention/protection against cerebral ischemic stroke.Entities:
Keywords: Cerebral ischemia/reperfusional; Ginkgo biloba L.; Neuroprotection; Polysaccharide; Purification
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Year: 2013 PMID： 24053818 DOI： 10.1016/j.carbpol.2013.07.045
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381