Literature DB >> 24052461

Proteinuria and VEGF-targeted therapies: 
an underestimated toxicity?

Hassane Izzedine1, Jean Charles Soria, Bernard Escudier.   

Abstract

Oncologists and nephrologists usually manage proteinuria related to anti-vascular endothelial growth factor (anti-VEGF) treatment only when it is in the nephrotic range or associated with renal insufficiency. This report is based on our personal experience with 78 patients developing renal problems with anti-VEGF therapy. We found that proteinuria induced by anti-VEGF therapy, even if weak and without associated renal insufficiency, may reflect a serious histological renal disease.

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Year:  2013        PMID: 24052461     DOI: 10.5301/jn.5000307

Source DB:  PubMed          Journal:  J Nephrol        ISSN: 1121-8428            Impact factor:   3.902


  5 in total

Review 1.  Renal Toxicities of Targeted Therapies.

Authors:  Anum Abbas; Mohsin M Mirza; Apar Kishor Ganti; Ketki Tendulkar
Journal:  Target Oncol       Date:  2015-12       Impact factor: 4.493

2.  Optimization of artificial urine formula for in vitro cellular study compared with native urine.

Authors:  Kanyarat Sueksakit; Visith Thongboonkerd
Journal:  Int J Med Sci       Date:  2021-07-23       Impact factor: 3.738

Review 3.  Safety and Tolerability of Anti-Angiogenic Protein Kinase Inhibitors and Vascular-Disrupting Agents in Cancer: Focus on Gastrointestinal Malignancies.

Authors:  Letizia Procaccio; Vera Damuzzo; Francesca Di Sarra; Alberto Russi; Federica Todino; Vincenzo Dadduzio; Francesca Bergamo; Alessandra Anna Prete; Sara Lonardi; Hans Prenen; Angelo Claudio Palozzo; Fotios Loupakis
Journal:  Drug Saf       Date:  2019-02       Impact factor: 5.228

Review 4.  Anti-VEGF Cancer Therapy in Nephrology Practice.

Authors:  Hassan Izzedine
Journal:  Int J Nephrol       Date:  2014-08-24

5.  Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data.

Authors:  Michael J Sorich; Andrew Rowland; Ganessan Kichenadasse; Richard J Woodman; Arduino A Mangoni
Journal:  Br J Cancer       Date:  2016-05-26       Impact factor: 7.640

  5 in total

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