Robert G Hahn1. 1. Research Unit, Södertälje Hospital, Södertälje, and Department of Anaesthesia, Linköping University, Linköping, Sweden.
Abstract
BACKGROUND: Glycine 1.5% has long maintained a dominating role as an irrigating solution for monopolar transurethral resection of the prostate (TURP), as well as for certain other transurethral procedures. MATERIALS AND METHODS: This review summarizes the findings of systematic experimental and clinical studies in which glycine 1.5% for irrigation was infused/absorbed and the outcome compared to at least one other irrigating fluid, including the isotonic saline used for bipolar TURP. RESULTS: There were 11 studies in animals, 3 in volunteers and 6 in patients undergoing TURP. With only one exception, which is probably due to low power, these studies either show a poorer outcome after administration or absorption of glycine solution or else that glycine 2.2% is more toxic than glycine 1.5%. The poorer outcomes consisted of more tissue damage or higher mortality (animals) or more symptoms (volunteers and patients). CONCLUSION: The safety of monopolar TURP would be improved by replacing glycine 1.5% with some other electrolyte-free fluid. The author argues that glycine 1.5% should be abandoned completely.
BACKGROUND:Glycine 1.5% has long maintained a dominating role as an irrigating solution for monopolar transurethral resection of the prostate (TURP), as well as for certain other transurethral procedures. MATERIALS AND METHODS: This review summarizes the findings of systematic experimental and clinical studies in which glycine 1.5% for irrigation was infused/absorbed and the outcome compared to at least one other irrigating fluid, including the isotonic saline used for bipolar TURP. RESULTS: There were 11 studies in animals, 3 in volunteers and 6 in patients undergoing TURP. With only one exception, which is probably due to low power, these studies either show a poorer outcome after administration or absorption of glycine solution or else that glycine 2.2% is more toxic than glycine 1.5%. The poorer outcomes consisted of more tissue damage or higher mortality (animals) or more symptoms (volunteers and patients). CONCLUSION: The safety of monopolar TURP would be improved by replacing glycine 1.5% with some other electrolyte-free fluid. The author argues that glycine 1.5% should be abandoned completely.
Authors: Marian S Wettstein; Cédric Poyet; Nico C Grossmann; Christian D Fankhauser; Etienne X Keller; Marko Kozomara; Salome Meyer; Tullio Sulser; Alexander Müller; Thomas Hermanns Journal: World J Urol Date: 2016-01-16 Impact factor: 4.226
Authors: Anwar S Atieh; Omar K Abu Shamma; Mohammad O Abdelhafez; Muath A Baniowda; Samia Abed; Basheer H Babaa; Abdurrahman Hamadah; Kamel A Gharaibeh Journal: Case Rep Nephrol Date: 2021-09-20